ISSN:
1432-1106
Keywords:
Spreading depression
;
Pupilla
;
Thalamus
;
Rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Spreading depression elicited in the thalamus of albino rats anesthetized with Dial by microinjection of 0.2–1.0 μl 25% KCl is accompanied by a maximal pupillary dilatation of the paralytic type. The mydriasis starts immediately after KCl application, culminates about 90 sec later and then slowly subsides with a half time of about 5 min. Although with lateralized KCl application thalamic spreading depression reaches the ipsilateral lateral geniculate body approximately 1 min earlier than the contralateral one, the pupillary reactions are strictly synchronous in both eyes. Participation of the sympathetic fibres was ruled out by the observation that thalamic spreading depression evokes the same mydriasis in the “encéphale isolé” rats. Cortical spreading depression, on the contrary, elicits only slight and shortlasting mydriasis. Comparison of the spatial march of spreading depression through the thalamus with the time course of the pupillary reaction indicates that the maximum mydriasis is probably caused by direct invasion of the Edinger-Westphal nucleus by the spreading depression process.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00240404
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