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  • 1
    Electronic Resource
    Electronic Resource
    Transforming and oncogenic activity of Simian SA 7 adenovirus DNA (1979)
    Springer
    Bulletin of experimental biology and medicine 88 (1979), S. 1450-1452 
    Details
    ISSN: 1573-8221
    Keywords: DNA ; transformation ; oncogenic activity ; restriction endonucleases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Transforming and oncogenic activity of whole Simian adenovirus SA 7 DNA (Ad SA 7) and of a mixture of its fragments produced by restriction endonucleases R. Bam HI and R. Sal I, was studied. Whole virus DNA was shown to transform rat kidney cells and rat embryonic fibroblasts and to induce tumor formation in newborn hamsters. Ad SA 7 DNA, hydrolyzed by R. Bam HI, possesses transforming activity; a mixture of DNA fragments produced by R. Sal I was oncogenic for hamsters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00830359
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  • 2
    Electronic Resource
    Electronic Resource
    Cell surface fibronectin and oncogenic transformation (1979)
    New York, N.Y. : Wiley-Blackwell
    Journal of Supramolecular Structure 11 (1979), S. 95-104 
    Details
    ISSN: 0091-7419
    Keywords: fibronectin structure and properties ; cytoskeleton ; cell surface proteins ; fibronectin distribution ; fibronectin interactions ; transformation ; Life Sciences ; Molecular Cell Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Fibronectin is a large glycoprotein at the cell surface of many different cell types; a related protein is present in plasma. Fibronectin is a dimer of 230,000-dalton subunits and also occurs in larger aggregates; it forms fibrillar networks at the cell surface, between cells and substrata and between adjacent cells, and it is not a typical membrane protein. Cell surface fibronectin is reduced in amount or absent on transformed cells and in many cases its loss correlates with acquisition of tumorigenicity and, in particular, metastatic ability. Exceptions to the correlations with transformation and tumorigenicity exist. Loss of fibronectin and the resulting reduced adhesion appear to be involved in pleiotrpoic alterations in cell behavior and may be responsible for several aspects of the transformed phenotype in vitro. Fibronectin interacts with other macromolecules (collagen/gelatin, fibrin/fibrinogen, proteoglycans) and is apparently connected to microfilaments inside the cell.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jss.400110110
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  • 3
    Electronic Resource
    Electronic Resource
    Flow cytometry analysis of early DNA content changes in human and monkey cells following infection with simian virus 40 (1979)
    New York, N.Y. : Wiley-Blackwell
    Journal of Supramolecular Structure 11 (1979), S. 25-31 
    Details
    ISSN: 0091-7419
    Keywords: simian virus 40 ; flow cytometry ; DNA synthesis induction ; transformation ; human diploid cells ; Life Sciences ; Molecular Cell Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Simian virus 40 (SV40) is capable of inducing cellular DNA synthesis in permissive and nonpermissive cells. Utilizing flow cytometry, we analyzed the DNA content changes in two diploid human cell strains and two monkey cell lines. The osteogenesis imperfects (OI) human skin fibroblasts were induced into DNA synthesis, and within one to two cell generations, a polyploid cell population was produced. With WI-38 phase II cells, a similar pattern of increased cycling of cells into DNA synthesis was observed; however, the majority (∼60%) of the cells were blocked in the G2 + M phase of the cell cycle. At later time intervals, an increase in the G1 population was demonstrated. The two monkey cell lines responded to SV40 virus with an accumulation of cells in the G2 + M phase of the cell cycle. Thus, two diploid human cell strains exhibited different cell cycle kinetics early after infection with SV40 virus. The one strain (WI-38) behaved similarly to the two monkey cell lines studied. The other strain (OI) responded similarly to nonpermissive (transformin) cells infected with SV40 virus.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jss.400110104
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  • 4
    Electronic Resource
    Electronic Resource
    BCG-activated macrophages in an in vitro assay for neoplastic cells (1978)
    Springer
    Methods in cell science 4 (1978), S. 841-844 
    Details
    ISSN: 1573-0603
    Keywords: BCG-activation ; macrophages ; transformation ; malignancy ; cultured cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00918411
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of dimethylsulfoxide on transformation ofBacillus subtilis in vitro (1978)
    Springer
    Bulletin of experimental biology and medicine 86 (1978), S. 1467-1469 
    Details
    ISSN: 1573-8221
    Keywords: dimethyl sulfoxide ; transformation ; deoxyribonuclease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Transformation ofBacillus subtilis was carried out in the presence of dimethyl sulfoxide and polyethylene glycol. The frequency of transformation ofB. subtilis was increased by 0.1% dimethyl sulfoxide but was not appreciably changed by polyethylene glycol. It is suggested that the increase in frequency of transformation was due to the effect of dimethyl sulfoxide on permeability of the cell membrane or to changes in membrane deoxyribonuclease activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00800287
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  • 6
    Electronic Resource
    Electronic Resource
    Changes in rous virus and polyoma virus during their synthesis in cells of unnatural hosts (1978)
    Springer
    Bulletin of experimental biology and medicine 86 (1978), S. 1639-1642 
    Details
    ISSN: 1573-8221
    Keywords: human embryonic tissue ; Rous fowl sarcoma virus ; transformation ; polyoma virus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A line of human embryonic fibroblasts, transformed by Rous sarcoma virus (Schmidt-Ruppin strain) contained and produced Rous virus, as was shown by the complement fixation and immunofluorescent tests, by electron-microscopic investigation, and by the presence of an isotope peak in a sucrose gradient. By its biological properties the synthesized virus differed from the original Schmidt-Ruppin strain for, in particular, the range of cells sensitive to the virus and its protein membrane were changed. Similar data indicating a change in the biological properties of a virus produced in the tissue of an unnatural host also were obtained for polyoma virus, synthesized in human embryonic fibroblasts transformed by it.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00801826
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  • 7
    Electronic Resource
    Electronic Resource
    Maximally correlated orthogonal composites and oblique factor analytic solutions (1977)
    Springer
    Psychometrika 42 (1977), S. 439-442 
    Details
    ISSN: 1860-0980
    Keywords: factor analysis ; Procrustes ; transformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Psychology
    Notes: Abstract Kaiser presented a method for finding a set of derived orthogonal variables which correlate maximally with a set of original variables. A simpler, more complete derivation of Kaiser's result is given and compared to related types of transformations. The transformation derived here suggests a direct method for finding the orthogonal factor solution which is maximally similar to a given oblique solution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02293661
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  • 8
    Electronic Resource
    Electronic Resource
    Distribution of glycoconjugates in mouse fibroblasts with varying degrees of tumorigenicity (1977)
    New York, N.Y. : Wiley-Blackwell
    Journal of Supramolecular Structure 7 (1977), S. 91-100 
    Details
    ISSN: 0091-7419
    Keywords: glycoconjugate ; glycosaminoglycan ; hyaluronic acid ; transformation ; tumorigenicity ; Life Sciences ; Molecular Cell Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Analysis of glucosamine labeled glycoconjugates in cultured cells has been made comparing 2 clones and the parent embryonic mouse cell line. Hyaluronic acid, heparan sulphate, and chondroitin sulphate as well as a complex mixture of glycopeptides were found in the medium, the trypsinate, and the trypsinized cells, although the distribution was not uniform. The 3 cell lines had very similar in vitro growth properties, including their plating efficiency in viscous medium. However, the tumorigenicity of the cells, determined in syngeneic mice, was found to differ. All 3 cell lines were found to have similar glycoconjugate distributions, although a slight relative increase in labeled hyaluronic acid was found in the more tumorigenic mass cell line than either of the clones. The possible significance of this increase is discussed.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jss.400070109
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  • 9
    Electronic Resource
    Electronic Resource
    Synthesis, secretion, and attachment of lets glycoprotein in normal and transformed cells (1977)
    New York, N.Y. : Wiley-Blackwell
    Journal of Supramolecular Structure 7 (1977), S. 397-408 
    Details
    ISSN: 0091-7419
    Keywords: LETS protein ; biosynthesis ; adhesion ; transformation ; cytoskeleton ; Life Sciences ; Molecular Cell Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: LETS glycoprotein is a surface glycoprotein which is absent or greatly diminished on the surfaces of transformed cells. Normal cells secrete large amounts of this protein into the medium; transformed cell medium contains much less. The difference is not due to degradation of the soluble LETS protein. Biosynthesis of LETS protein can be studied by analysis of cell extracts by detergent extraction and immune precipitation and appears to proceed in transformed cells at a reduced rate compared with normal cells. Addition of inhibitors of protein synthesis to transformed cell cultures causes the small amount of LETS protein in the medium to attach to the cells. Addition of normal conditioned medium, which contains LETS protein, to transformed cells alters their morphology towards normal. Addition of purified LETS protein to transformed cells causes the cells to attach, spread, align with one another, and regain actin cables. The results indicate that LETS protein can exchange between cell surface and medium and that it affects cellular adhesion, morphology, and cytoskeleton.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jss.400070311
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  • 10
    Electronic Resource
    Electronic Resource
    Dosage compensation and ontogenic expression of suppressed and transformed Vermilion flies in Drosophila (1975)
    Springer
    Biochemical genetics 13 (1975), S. 29-43 
    Details
    ISSN: 1573-4927
    Keywords: dosage compensation ; ontogenic expression ; transformation ; tryptophan oxygenase, Drosophila melanogaster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A spectrofluorometric assay system for tryptophan oxygenase was used to compare dosage compensation properties and ontogenic expression of suppressed, “transformed,” and wild-type vermilion flies. The results indicate that, although different stocks showed different levels of oxygenase activity, all showed dosage compensation properties. The ontogenic expression of tryptophan oxygenase was observed to be different in the various genotypes. Whereas suppressed vermilion resembled wild type in its pattern, the ontogenic profiles of “transformed” flies were different.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00486004
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