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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Anatomy and embryology 128 (1969), S. 222-234 
    ISSN: 1432-0568
    Keywords: Postnatal development ; Fixation ; Neuroglia ; Corpus callosum ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Gehirne von Tieren aus 4 verschieden alten Würfen junger Katzen wurden teils lebensfrisch durch Perfusion, teils nach 24 Std durch Immersion fixiert und für Vergleichsuntersuchungen in Paraffin eingebettet. Bei Betrachtung der Gliazellen des Corpus callosum ergab sich: 1. Nach Perfusionsfixierung sind die Kerne der Gliazellen groß und elliptisch. Sie sind wasserklar und haben eine scharf gezeichnete Chromatinstruktur. Nach Immersionsfixierung 24 Std p.m. sind die Kerne dagegen klein und rund, homogen dunkel gefärbt und haben ein kaum zu erkennendes Chromatingerüst. 2. Nach Perfusionsfixierung sieht man im Balken der ganz jungen Tiere zahlreiche Mitosen. Sie fehlen bei den durch Immersion fixierten Geschwistertieren desselben Wurfes. 3. Die nach verschiedener Fixierung beobachteten Unterschiede in der Form der Gliazellkerne werden durch Messungen der Quer- und Längsachsen erfaßt.
    Notes: Summary In four litters of young cats, some of the brains were fixed by perfusion and the others by immersion. The material was embedded in paraffin and the neuroglia was investigated in sections through the corpus callosum. It was found that: 1. After fixation by perfusion the nuclei of the glia cells are large and elliptic. The caryoplasm is clear and there is a distinct structure of the chromatin. After fixation by immersion the nuclei of the same cells are small and round. The caryoplasm is dense and the structure of the chromatin is not clearly visible. 2. After fixation by perfusion mitotic figures are present. They are absent in the brains fixed by immersion. 3. Following different fixation, there are differences in the shape of the nuclei of the glial cells. These differences have been investigated in detail by measuring the diameters of the nuclei.
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Anatomy and embryology 128 (1969), S. 28-39 
    ISSN: 1432-0568
    Keywords: Arterial supply ; Corpus callosum ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An 27 Katzen beiderlei Geschlechts wurde die Blutversorgung des Corpus callosum untersucht. Dabei wurden folgende Befunde erhoben: Der Balken der Katze wird im Bereich des Rostrum und Genu sowie im vorderen und mittleren Truncuabschnitt aus der Arteria cerebri anterior versorgt und zwar über Äste, die den Arteriae pericallosae und den Arteriae genu corporis callosi entstammen. Diese Äste wurden als Arteriae callosi superiores und inferiores bezeichnet. Lediglich im hinteren Truncusabschnitt und im Splenium erfolgt die Versorgung neben Ästen der A. pericall. auch über solche der Arteriae cerebri mediae und posteriores. Die Blutgefäße treten dolchartig in den Balken ein, teilen sich dann baumartig weiter auf und gehen in ein Capillarnetz über, das in Richtung des Nervenfaserverlaufes ausgezogen ist. Auf in der Literatur bereits bekannte, aber oft vernachlässigte Besonderheiten der Arteria carotis interna und des Circulus arteriosus wird hingewiesen.
    Notes: Summary In investigations on 27 cats of both sexes, the arterial supply of the corpus callosum was studied. The findings are as follows: In the region comprising rostrum and genu as well as in the fore and middle trunk sections, blood supplied by branches of the arteriae pericallosae and the arteriae genu corporis callosi which originate from the arteria cerebri anterior. These branches were designated arteriae callosi superiores and inferiores. However, in the posterior section of the trunk and in the splenium the blood is supplied by branches of the aa. pericall. and, in addition, by branches of the arteriae cerebri media and posteriores. The blood vessels penetrate the corpus callosum in bayonet fashion, then arborise and finally become a capillary network which is elongated in the direction of the course of the nerve fibres. Attention is drawn to peculiarities of the arteria carotis interna and the circle of Willis which, although known in the literature, are rarely referred to.
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 8 (1969), S. 113-129 
    ISSN: 1432-1106
    Keywords: Emotional behaviour ; Hypothalamus ; Electrical stimulation ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Affective behaviour patterns produced by electrical stimulation of the hypothalamus were studied in unanaesthetized, freely-moving cats. Bipolar stimulation with coaxial electrodes and small cathode was used to elicit defence, attack or flight. The development of these responses was studied by varying stimulation strength. In some experiments a stuffed animal was introduced in order to study the reactions of the cat to changes in the environment during stimulation. 2. The following responses were evoked at threshold intensity: (i) growling reaction; (ii) hissing reaction; (iii) two types of flight — type a preceded by hastily looking to and fro as if in search of an exit, type b preceded by inspection of surroundings, in most cases associated with sniffing. 3. Increasing stimulation 1.5 times threshold often yielded combined patterns. At points yielding the growling reaction a defence response in which growls alternated with hisses was obtained. The points yielding flight type a sometimes yielded hissing followed by flight. Increasing stimulation at hissing points yielded either a defence reaction or the combined effect hissing-flight. 4. The growling reactions were obtained from the tuber region. The hissing responses were obtained from points above the tuber. The flight reactions, type a, were produced from the intermediate zone extending from the level of the preoptic area to the mamillary bodies and type b from the caudo-lateral hypothalamus. 5. The reactions of the cats to a dummy during stimulation varied depending on the type of response which had been evoked in the absence of the dummy. The defence reaction was converted into threatening and striking of the dummy, the combined effects into threatening, striking or biting, culminating in sudden flight. The dummy was ignored during stimulation of points yielding flight type a, but examined by sniffing during stimulation of points yielding flight type b.
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  • 4
    ISSN: 1432-1106
    Keywords: Emotional Behaviour ; Hypothalamus ; Electrical stimulation ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The results presented in the present paper are an extension of preceding work devoted to exploration of the hypothalamic defence and flight fields using coaxial electrodes with small cathode. In 33 cats simultaneous stimulation was applied to two points which upon single stimulation had yielded defence, flight, or defence and flight respectively. Results were compared with those produced at either point alone. In 2 cats combined stimulation of a defence and a flight point was carried out with a stuffed cat present. 2. The latencies and rates of the vocal effects associated with defence (growling and hissing), and the latencies of flight (jump from the table) were measured. 3. Simultaneous stimulation of two points which had yielded defence, or of two points which had yielded flight resulted in facilitation (spatial summation) of the effects evoked: a more complete defence response associated with decrease of the latencies and increase in the rates of the vocal effects; decrease of flight latencies and increase of flight impetuosity. 4. Simultaneous stimulation of a defence point which had yielded growling at lower threshold than hissing, and of a point which had yielded flight resulted in facilitation of hissing. Growling and flight were often suppressed; when they occurred, latencies were lengthened and growling rates were increased somewhat. 5. Stimulation of a defence point with a dummy present produces striking (fending off). Simultaneous stimulation of a flight point resulted in facilitation of both hissing and striking. 6. It is concluded that the complex patterns obtained when defence is combined with flight are the result of facilitatory and inhibitory interaction between the elements of the individual patterns.
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 8 (1969), S. 37-52 
    ISSN: 1432-1106
    Keywords: Retinal Ganglion Cells ; Spatial Summation ; Center Inhibition ; Dynamic Organisation of Receptive Fields ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. An retinalen Ganglienzellen der Katze wurde die räumliche Summation im receptiven Feldzentrum (KFZ) bei Dunkeladaptation und Helladaptation durch mittelpunktzentrierte Lichtreize verschiedener Flächengrößen untersucht. Als Kriterium dienten die Entladungsraten der ersten 200 und 500 msec nach Licht-an oder Licht-aus. Das Summationsverhalten wurde sowohl für Einzelneurone als auch gruppenstatistisch für die beiden Neuronen-Systeme B (on-Zentrum) und D (off-Zentrum) untersucht. 2. Die räumliche Summation ist auf den inneren Bereich des RFZ beschränkt: bei on-Zentrum-Neuronen steigt die Entladungsrate nur bis zu Reizflächen, die etwa 1/5 der Fläche des RFZ belichten, bei off-Zentrum-Neuronen bis zu Reizflachen von ca. 1/10 des RFZ. Bei Variation der Reizfläche zwischen 20 und 100% der Fläche des RFZ bleibt das Entladungsniveau konstant (asymptotischer Verlauf der Summationskurve). 3. Die Begrenzung der räumlichen Summation auf einen kleinen Bereich des RFZ beweist eine bereits im Feldzentrum wirksame Hemmung. Diese Zentrum-Inhibition begrenzt die Erregungssummation im RFZ bei zunehmender Flächengröße des Lichtreizes. 4. On- und off-Zentrum-Neurone unterscheiden sich in beiden Adaptationszuständen in der Höhe des Entladungsniveaus. Die Entladungsraten der on-Zentrum-Neurone nach Licht-an übertreffen um ein Mehrfaches die Entladungsraten der off-Zentrum-Neurone nach Licht-aus. Die Unterschiede sind gruppenstatistisch hoch signifikant. Die interneuronale Variabilität der Entladungsraten ist bei den onZentrum Neuronen erheblich geringer als bei den off-Zentrum-Neuronen. 5. Dunkel -und Helladaptation führt zu signifikantem Unterschied der Entladungsraten: bei Helladaptation liegt die Impulsrate beider Neuronentypen höher als bei Dunkeladaptation und der Summationsbereich ist um 5–10% größer. 6. Für die mathematische Beschreibung der Summationsverläufe ist die Hyperbel besser geeignet als die logarithmische und Potenzfunktion. Logarithmus- und Potenzfunktionen beschreiben den konstanten asymptotischen Teil der Summationskurven ungenügend und eigenen sich nur für den Kurventeil im innersten Summationsbereich. Die Bedeutung der Befunde für eine dynamische Interpretation der visuellen Feldorganisation und mögliche Beziehungen zur lateralen Umfeldhemmung werden diskutiert.
    Notes: Summary 1. Spatial summation of suprathreshold light stimuli within receptive field centers (RFZ) of retinal ganglion cells was investigated during dark and light adaptation in cats. The mean discharge rates for 200 and 500 msec following light on or off were the computed response criteria. The summation effects were analyzed for single neurones and statistically for grouped neuron populations of the two neuronal subsystems B (on-center-neurones) and D (off-center-neurones). 2. Spatial summation is restricted to a small part of the RFZ. On-centerneurones increase their on-discharge rates with increasing spot sizes, only if the stimulus illuminates less than 1/5 of the RFZ. The summating area of the off-centerneurones is smaller (about 1/10 of the RFZ). 3. The limitation of spatial summation to a small part of the RFZ indicates the existance of inhibition within the RFZ. This center-inhibition sets a constant limit for excitation summation in the RFZ. 4. The mean neuronal response rates for the 2 subsystems show significant differences: The on-discharges of the on-center-neurones exceed the off-discharges of the off-center-neurones by a factor of 3–5. These highly significant differences occur at both adaptation levels and are not due to different spontaneous activity. Interneuronal response variability of the off-center-neurones was twice as large as that of the on-center-neurones. 5. Change from dark to light adaptation had only a small but significant influence on summation properties. The poststimulus discharge rates were higher during light adaptation and the summating area was slightly larger (about 5–10%). 6. A comparative curve fitting procedure for three suitable mathematical functions revealed that the hyperbola describes the neuronal summation curves better than a logarithmic or power function. The latter do not fit the constant asymptotic part of the curve. The significance of the results for a dynamic interpretation of the organisation of visual receptive fields is discussed.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 8 (1969), S. 219-231 
    ISSN: 1432-1106
    Keywords: Cerebral cortex in vitro ; Chloride transport ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The kinetics of the uptake of chloride by slices of cat cerebral cortex incubated in vitro have been studied for a wide range of concentrations of chloride and potassium in the incubation media. 1. In studies with 36Cl at a constant concentration of external K+, the rate of entry of chloride into slices of cat cerebral cortex (after equilibration with the fluid of the extracellular space) followed Michaelis-Menten kinetics with Vmax=7.7 μmoles/g/min and Km=245 mM. The kinetic data so described differ significantly from a curve describing simple diffusion (P 〈 0.02). 2. A clear dependence on concentration of K+ in the incubation medium was demonstrated. When external chloride was held constant at 6.8 mM and concentrations of potassium were varied over a range of 27–100 mM, the apparent rate of entry of chloride followed Michaelis-Menten kinetics with Vmax=0.191 μmoles/ g/min and Km=30.3 mM. 3. Under similar equilibrium conditions, the rate of influx of chloride was not statistically different from the rate of efflux, and the value for extracellular space (355 μl/g) derived by extrapolation from efflux data was of an identical order of magnitude to the value (352 μl/g) obtained from influx data. These values are essentially identical to those previously determined for chloride space of cat cerebral cortex in vivo (Bourke, Greenberg and Tower 1965). 4. The total, membrane-delimited content of chloride in cerebral cortex, as defined in these studies in vitro, was a function of the concentration of K+ in the incubation medium.
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 8 (1969), S. 232-248 
    ISSN: 1432-1106
    Keywords: Cerebral cortex in vitro ; Edema ; Fluid compartmentation ; Chloride transport ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ionic parameters of incubation media which foster both the development and subsequent reduction of swelling of slices of cerebral cortex under isosmotic conditions of incubation in vitro are described. A linear relationship between increasing chloride concentrations in incubation media and progressive swelling of tissue slices (under conditions of constant temperature and K+ concentrations and isotonicity of incubation media) is demonstrated. Subsequent reduction of chloride concentration in incubation media together with reciprocal replacement by isethionate is associated with significant and characteristic reduction in the volume of tissue swelling when all other conditions of incubation, including isotonicity of the media, are kept constant. The ionic composition of the fluid of swelling under different conditions of incubation is derived together with the ionic composition and expected transmembrane potentials of the neuronal compartment of cerebral cortex in vitro. Mechanisms involved in the development and subsequent reduction of swelling of cerebral cortex in vitro are discussed, and proposals for possible clinical applications are suggested.
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  • 8
    ISSN: 1432-1106
    Keywords: Lateral geniculate body ; Spatial summation ; Off-center-characteristics ; Geniculate transfer ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. Die räumliche Summation im receptiven Feldzentrum von Neuronen des Corpus geniculatum laterale (CG-L) wird beschrieben und mit entsprechenden Untersuchungen an retinalen Ganglienzellen verglichen. Neben größerer interneuronaler Variabilität ergeben sich ausgeprägtere Unterschiede der Summationseigenschaften der on-und off-Zentrum-Neurone. Der effektive Summationsbereich von etwa 1/5 der Fläche des RFZ ist in Retina und CGL etwa gleich. 2. Die on-Zentrum-Neurone des CGL zeigen in beiden Adaptationszuständen einen ähnlichen Summationsverlauf wie in der Retina. Das Entladungsnieau ist im CGL jedoch erheblich geringer und nicht durch Unterschiede in der Spontanaktivität zu erklären. 3. Die Mehrzahl der off-Zentrum-Neurone des CGL zeigt bei DA inverse Summationsverläufe wie in der Retina: durchgehende Verminderung der Entladungsrate der off-Antworten bei Vergrößerung der Reizfläche im RFZ. Eine kleine Gruppe zeigt einen parabelförmigen Summationsverlauf mit Entladungszunahme bis zu Reizflächen von 10–30% der Fläche des RFZ und darauffolgender Entladungsminderung. Bei Helladaptation zeigen fast alle off-Zentrum-Neurone diesen Parabelverlauf. Das durchschnittliche Entladungsniveau ist von dem retinaler offZentrum-Neurone nicht signifikant verschieden. 4. Die interneuronale Variabilität der Summationsvorgänge im RFZ von CGLNeuronen ist gegenüber den retinalen Ganglienzellen deutlich größer. Dies gilt insbesondere für die off-Zentrum-Neurone. Das Summationsverhalten von CGLNeuronen läßt sich daher nicht wie in der Retina durch einen Funktionstyp beschreiben. 5. Die Befunde sprechen für eine Transformation des retinalen Eingangs der off-Zentrum-Neurone im CGL, während die on-Zentrum-Neurone außer der bekannten Frequenzuntersetzung keine wesentliche Umformung erkennen lassen.
    Notes: Summary 1. Spatial summation in the receptive field center of neurones of the lateral geniculate body (CGL) is limited by inhibition to a small part of field center. Variations of stimulus size are only effective if the stimulus is smaller than about 1/5 of the area of receptive field center. Thus, the active summating area of the field center in the CGL corresponds to that of the retina. Geniculate neurones, however, show less homogeneous responses and the summation properties of the two neuronal subsystems (on-center-and off-center-cells), show greater differences than in the retina. 2. The form of summation curves for the on-center-neurones of the CGL is similar to those of the retina at both adaptation levels. However, the average responses rates in the CGL are considerably lower. This is not due to differences of spontaneous activity. 3. The summation characteristics of off-responses of off-center-neurones of the CGL are quite different from those in the retina. In dark adaptation the majority of CGL neurones respond with decreasing discharge rates to increasing spot-sizes within the field center. A small number show an initial increase of discharge rates up to stimulus sizes of about 1/10 of the receptive field center before a decrease occurs. This parabolic summation type is typical for most off-center-neurones in light adaptation. The mean discharge levels are the same as those of the retinal offcenter-neurones. 4. The higher interneuronal variability of summation curves especially of the off-center-neurones of the CGL indicates a more complex determination of the discharge properties of CGL neurones. This functional differentiation of single neurones is congruent with the more complex structural and synaptic organisation in CGL. 5. With respect to spatial summation, the results indicate a transformation of the retinal input of the off-center-neurones at the geniculate level, whereas the oncenter-neurones are nearly unchanged.
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 8 (1969), S. 79-96 
    ISSN: 1432-1106
    Keywords: Evoked potential thresholds ; Factor analysis ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zur Beschreibung von Korrelationen zwischen zahlreichen elektrophysiologischen Daten aus verschiedenen Hirngebieten wurde eine Faktorenanalyse nach der Hauptachsenmethode gerechnet. Ausgangsmaterial dieser Analyse waren Schwellen subcortical ausgelöster und abgeleiteter Antwortpotentiale auf Einzelreize. Das resultierende Faktorenmuster ermöglicht ein quantitatives Konzept der Schwellendetermination subcorticaler Reizantworten und zugleich ein Modell von Funktionsbeziehungen zwischen einigen Hirnstrukturen. Die Reizungen und Ableitungen erfolgten bei 35 encéphale isolé-Katzen mit Hilfe bipolarer Elektroden in folgenden Arealen: Amygdala, Hippocampus, Septum, N. dorsomedialis Thalami, Hypothalamus posterior und Formatio reticularis mesencephali. Es wurden 435 Korrelationskoeffizienten zwischen den Schwellen von 30 subcorticalen Verbindungen gebildet und zum Zwecke einer Datenreduktion durch eine Matrix von 5 Faktoren reproduziert. 1. Jeder Faktor repräsentierte hohe Schwellenkorrelationen zwischen den efferenten Projektionen jeweils eines Kerngebietes. Demnach nimmt im allgemeinen die Aktivität des Reizortes den größten Einfluß auf die Schwelle eines Antwortpotentials. Diese Hypothese ist durch pharmakologische Untersuchungen belegt worden [27] 2. Kovariationen von Reizantworten mit identischen Ableiteorten ergaben sich ausnahmslos, wenn die Latenzzeiten mehr als 11 msec betrugen. 3. Zusätzlich zeigte die Faktorenmatrix Schwellenkorrelationen zwischen: a) den hypothalamischen Efferenzen und mehreren hippokampalen Afferenzen langer Latenz (positive Korrelationen) b) retikulo-limbischen Verbindungen und „primären” Efferenzen von Amygdala und Hippocampus (positive Korrelationen) c) Antwortpotentialen, die durch Reizung der Formatio reticularis, und solchen, die durch Reizung des N. Amygdalae ausgelöst waren (negative Korrelationen) d) den Efferenzen des N. dorsomedialis Thalami und limbischen Projektionen langer Latenz zur mesencephalen Formatio reticularis (positive Korrelationen) Die Interpretation dieser Zusammenhänge bestätigt und erweitert einige bekannte Modelle von Beziehungen zwischen subcorticalen Kerngebieten. Abschließend wird mit Rücksicht auf die Linearität der mathematischen Methode die Anwendbarkeit der Faktorenanalyse auf Schwellen von Reizantworten diskutiert.
    Notes: Summary In 35 cats (encéphale isolé) evoked responses were elicited and recorded with bipolar electrodes from the amygdala, hippocampus, septum, dorsomedial thalamic nucleus, posterior hypothalamus, and mesencephalic reticular formation. Correlations between the thresholds of responses in different areas following stimulation of other areas were described by a factor analysis according to the principal axis method. 435 coefficients of correlation were calculated and reproduced by a matrix of 5 factors for the purpose of data reduction. Each factor represented high threshold correlations between the efferent projections of one region, which suggests that the activity of the stimulated site exerts a major influence on the evoked potential threshold. This is supported by pharmacological studies [27, 49]. Covariations of responses recorded in the same nucleus were always found, if the latencies exceeded 11 msec. The factor matrix indicated threshold correlations between: the efferent projections of the hypothalamus and several long latency afferent projections to the hippocampus (positive correlations); reticulo-limbic connections and “primary” efferent connections of the amygdala and hippocampus (positive correlations); evoked potentials following reticular and amygdaloid stimulation (negative correlations); the efferent projections of the dorsomedial thalamic nucleus and long latency limbic projections to the mesencephalic reticular formation (positive correlations). The interpretation of these relationships confirms and extends some well known models of relations between subcortical regions. The applicability of factor analysis to evoked potential thresholds is discussed with regard to the linearity of the mathematical method.
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  • 10
    ISSN: 1432-1106
    Keywords: Muscle spindle ; Gamma motor control ; Mesencephalic reticular formation ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Effects of repetitive stimulation of the mesencephalic reticular formation (MRF) on the static discharge and dynamic sensitivity of muscle spindle primary endings (soleus muscle) were studied in cats anaesthetized with Halothane (Fluothane). By progressive increasing the depth of anaesthesia three different fusimotor effects could be observed: 1. A static effect; the static discharge of the primary endings was strongly increased; the response to phasic stretch was decreased or remained unaltered. 2. A dynamic effect; the dynamic sensitivity of the primary endings was powerfully increased while the rate of discharge under static conditions was only slightly augmented. 3. A depressant effect; the static discharge and the dynamic sensitivity of primary endings were decreased. Repeated stimulation elicited successive static and dynamic effects. No specific regions within the MRF could be related to a particular effect.
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  • 11
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 9 (1969), S. 96-115 
    ISSN: 1432-1106
    Keywords: Pyramidal tract ; Fusimotor Neurons ; Forelimb ; Extensor ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of cortical stimulation upon dynamic and static sensitivities of the sensory endings in muscle spindles have been analyzed. 63 single afferent fibers from the muscle spindles of the forelimb extensors: M. flexor carpi radialis, M. flexor digitorum communis and M. palmaris longus were isolated in dorsal root filaments in 20 adult cats under chloralose-urethane anesthesia. They were identified by their response to stimulation of the median nerve. 1. Surface anodal repetitive stimulation of the anterior sigmoid gyrus was found to produce an enhancement of static response of single Group II fibers. Effective area was localized in a restricted region which corresponded to the forelimb motor area. The effect was obtained without any concomitant muscle contraction. Similarly, the stimulation increased the resting discharges of the Group Ia fibers from the same muscles. 2. Stimulation of the same area in the cerebral cortex was also found to increase the dynamic sensitivities of primary sensory endings. The increase was revealed by an enhancement of initial burst discharge during relaxation period of a twitch contraction caused by median nerve stimulation. 3. These results indicate that stimulation of the forelimb motor area has a facilitatory effect on both the static and dynamic fusimotor neurons innervating the muscle spindles of the test muscles. 4. The effects were reproduced in pyramidal tract preparations in which the brainstem was cut either at the level of the midbrain except for the cerebral peduncle or at the level of caudal medulla oblongata sparing the pyramid. 5. The threshold for the fusimotor effects was less than 1.3–1.5 times threshold of the pyramidal tract discharge, when the best spot for eliciting the fusimotor response was chosen. These results indicate that the effects of cortical stimulation are mainly mediated by the fast conducting pyramidal tract fibers.
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  • 12
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 9 (1969), S. 164-182 
    ISSN: 1432-1106
    Keywords: Emotional behaviour ; Hypothalamus ; Electricalstimulation ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. In order to compare the selective value of repetitive cathodal pulses of 8 c.p.s. and of continuous sine-wave alternating currents of 5000 c.p.s. (middle frequency current) when applied to brain tissue, explorations were made in the region of the hypothalamus that had yielded defence and/or flight reactions in earlier experiments. The region was explored by stimulating each point in turn with both current forms. At the same time measurement was made of the impedance of the brain tissue, and the effects produced by altering the time of rise of the middle frequency current on threshold of responses were also studied. The experiments were carried out on unanaesthetized, freely moving cats. 2. Both stimulation types produced affective (“emotional”) responses. The patterns elicited by low frequency cathodal pulse stimulation were often associated with stimulus-bound phasic muscle activity, i.e., flapping of ears, and twitching of whiskers, or, rotation of the head. Such extraneous motor effects were rarely obtained when continuous middle frequency currents were applied, and were tonic in character when present. 3. Mapping of reactive points revealed that the area producing defence or flight following middle frequency stimulation is smaller in size than the field delimited by means of repetitive cathodal pulse stimulation. These results strongly suggest that spread of current can be reduced by using middle frequency current stimulation. This apparently local (and hence highly selective) action is paralleled by a lower impedance of the brain tissue to the rapidly changing polarity of this current. 4. The hissing (and/or growling) associated with the defence pattern showed adaptation to suddenly rising middle frequency currents of 30 secs duration. An increase in threshold of hissing occurred when the time of rise of the current was prolonged. Flight, in contrast, was obtained at the same critical intensity regardless of the time of rise of current. 5. The nature of the stimulatory action of middle frequency current (examined in the peripheral nerve by Wyss) and the advantages presented by this new method of brain stimulation are briefly discussed.
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  • 13
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 9 (1969), S. 30-52 
    ISSN: 1432-1106
    Keywords: Climbing fibers ; Mossy fibers ; Vestibulo-cerebellar input ; Cat ; Frog ; Golgi cell inhibition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Field and unitary potentials evoked in the vestibulo-cerebellum of frog and cat following vestibular nerve stimulation were recorded with microelectrodes and correlated with their site of origin in the various layers of the cerebellar cortex. 2. In the frog, primary vestibular fibers project both as mossy and as climbing fibers onto the cerebellar auricular lobe. Secondary vestibulo-cerebellar fibers seem to end exclusively as mossy fibers in the auriculum. As a consequence of this dual projection, extra- and intracellular recordings from Purkinje cells in the auricular lobe show two kinds of responses to vestibular nerve stimulation: a) graded, repetitive firing mediated through mossy fiber-granule cell-parallel fiber pathways, and b) all-or-none burst responses caused by monosynaptic impingement of vestibular climbing fibers on Purkinje cells. 3. The field and unitary potentials evoked in the cat nodulus, flocculus and uvula following vestibular nerve stimulation are shown to be generated by mossy fibers exclusively. Considerable convergence of the two labyrinthine mossy fiber inputs to a given cerebellar area was found. 4. Interaction of contralateral and ipsilateral mossy fiber input at the level of the flocculus suggests that Golgi cell inhibition might operate not only as a simple inhibitory feedback loop, but also as a complex gating operator at the granule layer. 5. No short latency climbing fiber activation of Purkinje cells was observed following VIIIth nerve stimulation. Stimulation of the contralateral inferior olive evoked short latency climbing fiber EPSPs in Purkinje cells of the vestibulo-cerebellum. Suggestions are made as to the possible role of mossy and climbing fiber inputs to this area of the cerebellum.
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  • 14
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    Experimental brain research 9 (1969), S. 284-306 
    ISSN: 1432-1106
    Keywords: Cutaneous receptive fields ; Spinal cord ; Cat ; Pain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Examination of cutaneous receptive fields (RFs) of lamina 5 cells in the lumbar spinal cord of decerebrate cats shows them to have three distinct zones with respect to mechanical and electrical stimulation. The mean response rate to both mechanical and electrical stimulation in zone 1 increases steadily up to the highest strengths used; in zone 2, surrounding zone 1 mainly proximally, mild stimuli reduce the mean rate, stronger stimuli increase it; in zone 3, mainly proximal to zone 2, all stimuli reduce the rate. Temporally, zone 1, electric shocks near threshold produce bursts of firing followed by inhibition. With increased stimulus strength, the bursts lengthen to a second or more. In zones 2 and 3, inhibition at all strengths is preceded at higher strengths by bursts of firing. Cold-blocking the spinal cord at lower thoracic levels reversibly increases the ongoing activity of these cells, increases the area of zones 1 and 2, and almost completely suppresses all inhibition. Stimulation of dorsal columns and threshold stimulation of distant dorsal roots inhibits ongoing and induced activity. Barbiturate decreases ongoing activity and the duration of firing produced by cutaneous electrical stimulation but does not decrease inhibition. These results are consistent with a model in which low-threshold fibres are excitatory only over a small central area of the RF of a lamina 5 cell (zone 1), high threshold fibres are excitatory over a larger area (zones 1 and 2), and low threshold fibres are inhibitory over the entire receptive field (zones 1, 2 and 3) with a slower time-course. This inhibition is tonically enhanced by descending influences in the decerebrate cat. It is suggested that the high and low threshold fibres correspond approximately to the small and large diametre fibres whose balance is the basis for the coding of pain in the theory of melzack and wall.
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  • 15
    ISSN: 1432-1106
    Keywords: Muscle spindle ; Gamma motor control ; Reticular formations ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. During a progressive increase of Fluothane (Halothane) anaesthesia, repetitive stimulation of the mesencephalic retioular formation (MRF) produces several fusimotor effects — static, dynamic or depressant — on primary endings of soleus muscle spindles (Vedel et Mouillac-Baudevin 1969). 2. Transection of the brain immediately rostral to the site of stimulation may increase the dynamic effect but does not alter the static or the depressant effects. 3. A section of the rubrospinal tract does not modify the fusimotor effects elicited by stimulation of the MRF. 4. Transections of the spinal cord have shown that the pathways responsible for the transmission of these effects are mainly situated in the ipsilateral ventral and ventrolateral funiculi which contain the efferent fibers from the pontine reticular formation (PRF), from the bulbar reticular formation (BRF) and from the vestibular nucleus. 5. Contra and ipsilateral PRF stimulation produces the static fusimotor effect; contralateral stimulation from a small anterior region produces the dynamic effect. 6. Stimulation of the lateral part of the ipsilateral BRF elicits the dynamic effect while stimulation of the medial part elicits the static effect.
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  • 16
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    Naunyn-Schmiedeberg's archives of pharmacology 262 (1969), S. 73-86 
    ISSN: 1432-1912
    Keywords: Strophanthidine Derivatives ; Toxicity ; Absorption ; Guinea-Pig ; Cat ; Strophanthidinderivate ; Toxicität ; Resorption ; Meerschweinchen ; Katze
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurde die Wirksamkeit verschiedener Ester und Äther von Helveticosid und Helveticosol bei i.v. und intraduodenaler Zufuhr an Katzen und Meerschweinchen geprüft. 1. Bei i.v. Dauerinfusion waren Helveticosol und seine Derivate bei Meerschweinchen etwa doppelt so wirksam wie die analogen Helveticosidverbindungen. Bei der Katze bestand kein Unterschied. Die Monomethyläther Cymarin und Cymarol waren gleich oder sogar stärker wirksam, alle übrigen Derivate deutlich schwächer als die Ausgangssubstanzen. 2. Die tödlichen Dosen bei intraduodenaler Injektion lagen beim Meerschweinchen für einige Substanzen in gleicher Größenordnung oder niedriger als die Titer bei i.v. Infusion. Diese hohe enterale Wirksamkeit kann bei Helveticosid und seinen Derivaten durch eine Reduktion zu dem wirksameren Helveticosol, bei Estern außerdem durch eine Hydrolyse zu wirksameren Glykosiden vorgetäuscht werden. 3. Bei intraduodenaler Infusion an Katzen waren alle geprüften Ester und Äther wirksamer als Helveticosid und Helveticosol. Die aus dem Verhältnis der toxischen Dosen bei i.v. und intraduodenaler Infusion berechnete enterale Wirksamkeit lag zwischen 20 und 50%. 4. Unterschiede in der Dauer der intraduodenalen Infusion bei Katzen lassen sich berücksichtigen, wenn man von der theoretischen Annahme einer exponentiellen und vollständigen Resorption ausgeht und die Halbwertszeit für die Resorption berechnet. Die minimale Resorptionsgeschwindigkeit lag bei einigen Derivaten in gleicher Größenordnung wie bei Digoxin und Digitoxin. Es wird auf den Unterschied zwischen der auf Grund der pharmakologischen Wirkung bestimmten relativen enteralen Wirksamkeit und der Resorptionsquote hingewiesen. Letztere ist für die Verläßlichkeit der therapeutischen Wirkung eines Glykosids bei oraler Gabe maßgebend.
    Notes: Summary The efficacy of several esters and ethers of Helveticosid and Helveticosol was assayed by intravenous and intraduodenal administration to cats and guinea-pigs. 1. In guinea-pigs, Helveticosol and its derivatives were approximately twice as active on intravenous infusion as the analogous derivatives of Helveticosid; in cats there was no significant difference. The monomethylethers Cymarin and Cymarol were equally or slightly more potent, all other derivatives were weaker than the original compound. 2. In guinea-pigs the lethal doses of some compounds on intraduodenal injection were equal to or even lower than those on intravenous infusion. This may partly be accounted for by a reduction of Helveticosid and its derivatives to the more potent Helveticosol analogues, partly by a hydrolysis of the esters, yielding compounds of higher activity. 3. On intraduodenal infusion in cats, all the investigated esters and ethers were more active than Helveticosid and Helveticosol. The relative enteral activity calculated from the ratio of the toxic doses on intravenous and intraduodenal infusion varied between 20 and 50%. 4. Due to a delayed absorption from the gastrointestinal tract, the toxic dose falls with a reduced speed of intraduodenal infusion. Assuming an exponential and complete absorption, the half time of absorption was calculated. For some of the compounds investigated, the speed of absorption was comparable to that of Digoxin and Digitoxin. The difference between the relative enteral activities determined by comparing equiactive doses on enteral and parenteral administration and the percentages of the glycosides which are absorbed from the gastrointestinal tract is pointed out. The latter is of prime importance for obtaining reproducible effects after enteral administration.
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  • 17
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    Naunyn-Schmiedeberg's archives of pharmacology 264 (1969), S. 406-419 
    ISSN: 1432-1912
    Keywords: Intestinal Absorption ; Cardiac Glycosides ; Blood of Portal Vein ; Intestinal Lymph ; Cat ; Intestinale Resorption ; Herzglykoside ; Portalvenenblut ; Darmlymphe ; Katze
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The cardiac glyoosides digitoxin, ouabain, digoxin and peruvosid labelled with3H were injected into tied intestinal loops of anaesthetized cats in situ. The absorbed glycosides were measured in the blood of the portal vein and in the intestinal lymph. At the same time the3H-activity was measured in the blood of the peripheral circulation, in the bile and in the urine. 2. Calculation of the amount of glycosides totally absorbed from the3H-concentration in the blood of the portal vein and the circulation volume (bubble-flow-meter) gave the following absorption rates as a percentage of the administered dose per hour: digitoxin 56%, digoxin 42%, peruvosid 26% and ouabain 10%. 3. The amount of glycosides passing into the lymph during 1 hour was found to be only 0.006 to 0.02% of the amount offered. In lymph3H-activity cannot be measured earlier than 5 min after the administration of the labelled glycosides. The3H-concentration in the lymph did not equal that measured in the blood of the peripheral circulation until at least 1 hour after the administration and always remained below the3H-concentration of the blood in the portal vein. This proportion remained unchanged even if digitoxin was administered as an emulsion in oil instead of an aqueous solution. From the time course of3H-concentration it might be concluded that the glycosides do not pass directly to the lymph after absorption but indirectly by way of the blood. 4. The amount of glycoside excreted in the bile is for peruvosid 15,5% of the amount absorbed, for ouabain 1,9%, for digoxin 1,4% and for digitoxin 0,8%. The3H-activity excreted in urine is very small and can be disregarded. 5. Chromatographic analyses of the bile revealed, that in the case of digoxin, 4/5 of the amount excreted were unchanged, in the case of digitoxin and ouabain 2/3 and in the case of peruvosid only 1/4. In the lumen of the tied intestinal loops and in the tissue of the small intestine the glycosides were hardly metabolised.
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  • 18
    ISSN: 1432-2013
    Keywords: Cat ; Decerebration ; Afferents to Respiratory Centers ; Medulla Oblongata ; Reticular Formation ; Katze ; Decerebrierung ; Afferenzen zu Atemzentren ; Medulla oblongata ; Formatio reticularis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An 11 intercolliculär decerebrierten Katzen wurde geziegt, daß Kälteblockade eines eng umschriebenen Feldes auf der ventralen Oberfläche der Medulla oblongata, wie früher für anaesthesierte Tiere beschrieben, zu Atemstillstand führt, wenn die kontralaterale Stelle auf der Medulla oblongata, die Sinusnerven und die Vagi ausgeschaltet sind. Zu Atemstillstand kam es auch, wenn statt der Kälteblockade 2% Novocain durch lokale Superfusion bei gleichzeitiger Gegenspülung der Umgebung mit künstlichem Liquor angewandt wurde, oder wenn ein mit 1% Novocain getränkter Tupfer lokal aufgelegt wurde. Außerdem führte Kälteblockade zu Atemstillstand, wenn durch kontinuierliche auch während der Kälteblockade anhaltende elektrische Reizung eines N. femoralis oder hinterer Lumbalwurzeln an decerebrierten Katzen oder des Hypothalamus an einer anaesthesierten Katze Steigerungen der Ventilation ausgelöst worden waren. Elektrische Reizung eines Sinusnerven führte zu Atemsteigerungen. Bei Sinusnervenreizung während eines durch Kälteblockade ausgelösten Atemstillstands kam es zu rhythmischer Atmung. Aus diesen Untersuchungen wird geschlossen, daß mit der Ausschaltung der beschriebenen Felder auf der ventralen Oberfläche der Medulla oblongata am sonst desafferentierten Tier die Gesamtheit der für die zentrale CO2-Empfindlichkeit verantwortlichen Strukturen erfaßt ist, daß nach Ausschaltung der zentralen und der peripheren Chemosensibilität eine unspezifische Aktivierung der Atmungszentren unwirksam ist und daß die Atmungszentren zur Ausbildung einer rhythmischen Atmung von spezifischen Antrieben abhängig sind.
    Notes: Summary It was shown in 11 decerebrated cats, that cooling of a small and well defined area on the ventral surface of the medulla will cause respiratory arrest if the contralateral area of the medulla, the vagi and sinus nerves are eliminated. This confirms earlier observations obtained in anesthetized cats. Apnea was also produced by local superfusion of 2% procain with simultaneous flushing of the immediate surrounding area with mock spinal fluid. Local application of a small sponge soaked with 1% procain had the same effect. Electrical stimulation of femoral nerves or posterior roots which results in hyperventilation on the decerebrated cat failed to show any effect during periods of cold blockade. There was no respiratory response to direct stimulation of the hypothalamus in an anesthetized cat during cooling. Electrical stimulation of one sinus nerve caused an increase of ventilation. Sinus nerve stimulation during apnea induced by cold blockade resulted in rhythmical respiration. It is concluded from these experiments: Blocking of the area under discussion on the ventral surface of the medulla, inhibits all structures responsible for the central CO2-sensitivity in the deafferentiated animal. There was no response to non-specific stimuli of the respiratory center after elimination of central and peripheral chemosensitivity. The respiratory centers apparently depend on specific stimuli to support rhythmical respiration.
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  • 19
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    Pflügers Archiv 309 (1969), S. 285-309 
    ISSN: 1432-2013
    Keywords: Labyrinthine Stimulation ; Types of Abducens Neurones ; Frequency Analysis ; Cat ; Labyrinthreizung ; Abducensneurone ; Frequenzanalyse ; Katze
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Single cell activity was recorded extracellularly from neurones in cat's abducens nuclei in unanesthetized, decerebrate preparations. Two types of neurones were found. i) The motoneurones (type IIA) increased their firing linearly or exponentially to contralateral constant angular accelerations and decreased firing to ipsilateral rotation. The increased frequency was maintained at a constant level without any sign of adaptation. This constant level of maximum frequency was proportional to the logarithm of the acceleration applied. No significant differences of the frequency responses of tonic and silent motoneurones were found. The conduction velocities of the axons of spontaneously firing type IIA cells were slower than in silent neurones. Electrical stimulation of the contralateral VIIIth nerve led to activation of the type IIA cells; stimulation of the ipsilateral nerve resulted in inhibition of both spontaneous discharge and antidromic invasion of the motoneurones. ii) The type IA units increased their firing rate to ipsilateral rotation and ceased to discharge in response to contralateral rotation. They never were excited antidromically by stimulation of the VIth nerve. However, they were excited by stimulation of the ipsilateral VIIIth nerve. Their possible functional role in the vestibulo-ocular system was discussed.
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  • 20
    ISSN: 1432-1106
    Keywords: Lateral cervical nucleus ; Midbrain lesions ; Nauta method ; Ultrastructural investigation ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The lateral cervical nucleus (LCN) has been studied with the light and electron microscope after midbrain lesions in kittens of different ages, and in adult cats. It has been shown that nerve cells remain within the contralateral LCN after hemisection of the midbrain. performed on 1 day old kittens. The estimated number of these remaining cells was 3–19% in the different cases. No fibers descending to the LCN from levels rostral to the midbrain could be demonstrated in adult cats with the Nauta technique. A combined Nauta and electron microscopical investigation was performed on kittens operated on at different ages and allowed to survive varying times postoperatively. At the operations the LCN-axons were transected at midbrain level. The Nauta investigation demonstrated silver impregnation of degenerating LCN-neurons on the affected side of the same type as has been described recently in other neuronal systems following axonal transection. The ultrastructural study revealed electron dense degenerating dendrites and probably also nerve cells within the LCN. The dense degenerative changes were very similar to the dense degeneration in terminal boutons following transection of parent axons. The potential value of the findings for electron microscopical research in neuroanatomy is discussed. The results in terms of connections of the LCN are discussed in the light of known anatomical and physiological data of the LCN.
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  • 21
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    Experimental brain research 7 (1969), S. 68-83 
    ISSN: 1432-1106
    Keywords: Medial geniculate body ; Inhibition ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Inhibitory activity in the cat medial geniculate body (MG) was examined by stimulating electrically and acoustically the input and output of the MG. 2. A longer and more profound depression of excitability occurs following a click-evoked potential in the MG than in the inferior colliculus (IC) in both anesthetized and unanesthetized states. Recovery is cyclic in the barbiturate MG preparation. 3. Electrical stimulation of the brachium of the inferior colliculus (BIG) evokes a field potential in the MG consisting of clearly distinguishable presynaptic and postsynaptic components. The presynaptic component recovers rapidly, while the postsynaptic component requires 100–200 msec for full recovery. This depression of excitability is localized within the MG since cortical ablation does not alter its occurrence. 4. Stimulation of the BIC mimics the effects of click stimulation on single units. Excitatory, inhibitory and reverberatory responses are evoked by the BIC shock. Suppression of single unit activity correlates with the depression of excitability following a BIC-evoked field response. 5. Cortical stimulation can evoke antidromic and trans-synaptic unit responses in the MG, as well as causing a variety of inhibitory effects and reverberation. In view of the fact that cortical ablation does not impair the recording of these responses to afferent stimuli, it is suggested that the cortical-evoked responses are at least partly mediated by antidromic conduction to MG. 6. Evidence is presented that inhibitory effects of both afferent and cortical stimulation are due to active inhibition of MG unit activity. Speculations are made as to the mechanisms producing inhibition and reverberation in the MG.
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  • 22
    ISSN: 1432-1106
    Keywords: Electron microscopy ; Pontine nuclei ; Experimental neuroanatomy ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The electron microscopical changes occurring in the pontine nuclei following unilateral lesions of the primary sensorimotor cortex have been studied in 7 cats with a survival time from 2–23 days. A description is also given of the fine structure of the pontine regions in receipt of the fibres. These regions are shown in Fig. 1. The study shows that the boutons are practically only in synaptic contact with dendrites. The bouton density on these is only 16%. The boutons are of the en passage and terminal type, with the latter as the most common (Figs. 4a-e). The synaptic vesicles are rounded or elongated. The formaldehyde fixed material had 17.8% boutons with vesicles of the elongated type; the material fixed with a mixture of formaldehyde and glutaraldehyde had only 11.5% of such boutons. The degenerating boutons show the dark type of reaction and the majority of the corticopontine fibres are of the type shown in Figs. 4d and 4e. Astrocytes and microglial cells participate in the removal of degenerating boutons and terminal fibres. Degenerating boutons are present even at the 23 day stage and some have apparently only started to degenerate.
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  • 23
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    Experimental brain research 7 (1969), S. 32-50 
    ISSN: 1432-1106
    Keywords: Lateral cervical nucleus ; Spinal lesions ; Ultrastructural investigation ; Degenerating boutons ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ultrastructure of terminal degeneration within the lateral cervical nucleus (LCN) after transection of its spinal afferent fibers 2 days–2 years earlier is described. The degeneration after 2 days was of both the neurofilamentous and dense type. The highest number of degenerating terminals, about 15%, was found after 4–5 days. Then most of the degenerating boutons were of the dense type. The degenerating terminals had synaptic contact with cell bodies and dendrites of LCN-neurons. Removal of the degenerating boutons seemed to be effected by a phagocytic cell present in increased number compared to the normal LCN. In cases with long survival times an increase in the number of astroglial filaments was observed. In an animal where the spinal afferents to the LCN had been cut 2 years earlier a decrease in medium size of the neurons was observed. The amount of dendritic spines was also considerably smaller than normally.
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  • 24
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    Experimental brain research 7 (1969), S. 143-157 
    ISSN: 1432-1106
    Keywords: Reticular formation ; Convergence ; Inhibition ; Cat ; Chloralose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. Ein konditionierender corticaler Reiz inhibiert den somatischen Startlereflex bei Katzen unter Chloralosenarkose für eine Dauer von mehr als 200 ms. Die Interaktionen zwischen beiden Reizen laufen in der bulbären und pontinen Formatio reticularis ab. 2. Dem Startlereflex liegt eine polysynaptische Erregungsschleife zugrunde, die die bulbäre und pontine Formatio reticularis durchzieht. Die Resistenz der reticulären Neurone gegenüber repetitiver Stimulation wurde als Kriterium ihrer funktionellen Lokalisation auf dem polysynaptischen Reflexbogen gewertet. 3. Die corticale Inhibition wird im Verlaufe der polysynaptischen Erregungsschleife zunehmend stärker. Neurone, die von den Startlereflexafferenzen direkt erregt werden, werden durch den corticalen Reiz nicht inhibiert. Dies schliebt eine präsynaptische Inhibition der reticulopetalen Fasersysteme aus.
    Notes: Summary 1. The startle reflex evoked by cutaneous stimulation in cats under chloralose anesthesia is inhibited for more than 200 ms by a conditioning cortical volley. The interaction between the cutaneous and the cortical volley takes place in the bulbar and pontine reticular formation. 2. The startle reflex involves a series of reticular neurones. Resistance to repetitive stimulation has been determined to evaluate the functional localization of each neurone within this polysynaptic path. 3. Inhibition following the cortical volley becomes increasingly more effective along the course of the polysynaptic path and is completed within 5–6 ms. Reticular neurones excited directly by the spino-reticular afferents are not inhibited, thus excluding a presynaptic inhibition of the spinoreticular fibres.
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  • 25
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    Experimental brain research 7 (1969), S. 195-213 
    ISSN: 1432-1106
    Keywords: Corpus callosum ; EEG synchronization ; Homolateral sensory evoked potentials ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Spontaneous EEG-patterns and evoked potentials (EP's) of symmetrical cortical areas were recorded in chronic and acute cats before and after section of the corpus callosum, the commissura anterior and posterior and the massa intermedia. The spontaneous EEG was recorded without and with anesthesia, EP's after electrical stimulation of the fore-paws only during nembutal anesthesia. — No changes in the bilateral coordination of spontaneous and evoked EEG-patterns could be seen after commissurotomy (CT). The bilateral coherence of EEG-waves as revealed by cross-correlation is low already in the normal cats and does not change significantly after CT. The values of cross-correlation coefficients at T = ± 15 msec vary during one EEG-record between -0.25 and +0.25 in the somatosensory, suprasylvian and temporal areas (mean values slightly above 0). In the visual area occasionally positive values between 0.5 and 0.8 were seen, but also here a large variation was found in all animals and the mean values were below 0.1. No consistent phase shift between both sides was observed. EEG-patterns like spindles or arousal, still occurred together in both hemispheres after CT, the variability of their exact beginning or end was the same as in controls. Spontaneous spindles often lasted longer after section of the massa intermedia. Homolateral EP's in the somato-sensory area were still present after CT. Rhythmical afterdischarges could be restricted to the contralateral somato-sensory cortex even before CT.
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  • 26
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    Psychopharmacology 14 (1969), S. 164-166 
    ISSN: 1432-2072
    Keywords: Benperidolum ; Cat ; Extrapyramidal Side Effect ; EEG ; Toxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Daily doses of 1–10 mg Benperidol were given perorally to cats during 26 months. The general behaviour and the EEG were unchanged during the treatment, in particular no signs of dyskinesia were observed. After discontinuation of the administration, the behaviour and the EEG of the animals stayed normal. Thus no lasting and irreversible side effects could be observed.
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  • 27
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    Psychopharmacology 15 (1969), S. 382-391 
    ISSN: 1432-2072
    Keywords: LSD ; Retina ; LGN ; Single Unit Activity ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of LSD 25 (i. v. injection) on the spontaneous and evoked activity of the visual system was investigated in cats. 50 γ/kg did not change significantly the ERG and the visual cortical evoked potential. The spontaneous discharge rate of 14 out of 21 retinal ganglion cells showed an increase which reached its maximum within 20–30 min and which could still be present 1 hour following the injection. One third of the retinal units showed a slight depression of their spontaneous dischaRge rate with about the same time course. Single units of the LGN showed about the same behaviour. The response to light stimulation was slightly increased in some units and light induced inhibition was slightly shortened. The possible mechanism of the LSD-effect on retinal ganglion cell activity is discussed.
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  • 28
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    Cell & tissue research 101 (1969), S. 607-620 
    ISSN: 1432-0878
    Keywords: Glandula bulbourethralis ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Das Parenchym der Glandula bulbourethralis der Katze besteht aus weitlumigen, gebuchteten intraglandulären Gängen, in welche kurze, englumige, zumeist unverzweigte Tubuli einmünden. Der Drüse fehlt eine äußere Organkapsel, so daß ihre peripheren Tubuli stellenweise direkt zwischen den Fasern des quergestreiften M. bulboglandularis liegen. Die Drüsentubuli und die Buchten der intraglandulären Gänge sind mit einem einschichtigen Zylinderepithel ausgekleidet, auf den Gangfalten ist das Epithel abschnittsweise mehrreihig, Die sezernierende Epitheloberfläche ist durch die Ausbildung von interzellulären Sekretkapillaren vergrößert. Breite Zwischenzellspalten (Durchmesser etwa 1,5μ), in welche schlanke interdigitierende Cytoplasmafortsätze hineinragen, erstrecken sich von der Basalmembran bis kurz unter das Tubulusbzw. Ganglumen. Die lumenseitigen Zellgrenzen tragen einige stummelförmige Mikrovilli und besitzen zerklüftete Außenkonturen, die durch glykogenreiche Cytoplasmaprojektionen bedingt sind. Alle Epithelzellen sind reich an Mitochondrien. Die supranuklearen Abschnitte der meisten Gang- und Tubuluszellen enthalten Sekretgranula, welche im Elektronenmikroskop unterschiedliche optische Dichten aufweisen können. Die Granula enthalten ein PAS-positives, neuraminsäurehaltiges epitheliales Muzin, das in einzelnen Sekretkörnchen auch eine histochemische Reaktion auf Sulfatgruppen gibt. Alle Epithelzellen reagieren sehr stark auf unspezifische Esterase und stark auf β-D-Glucuronidase, β-D-Glactosidase sowie die Enzyme des Citronensäurezyklus, der Glykolyse und der Atmungskette (NAD-ICDH, SDH, ALD, LDH, ADH, GDH, NADH-T-Red, Cyt-Ox).
    Notes: Summary The bulbourethral glands of sexually mature male cats are studied with the light and electron microscope. The parenchyma consists of spacious, sinus-like intraglandular ducts and short, narrow, mostly unbranched tubular endpieces. The gland has no complete connective tissue capsule, consequently some of the peripheral tubules are situated directly in between the fibers of the surrounding bulboglandularis muscle. The endpieces and the sinus of the intraglandular ducts are lined by a simple columnar epithelium, whereas the folds of the ducts are generally covered by a low pseudostratified epithelium. The secretory surface of the cells is increased by intercellular canaliculi which communicate with the gland lumen. These canaliculi are identified on the light microscopic level by their strong 5′-nucleotidase activity. Furthermore widened intercellular spaces (approximately 1,5 μ in diameter) filled with slender, interdigitating cytoplasmic processes extend from the basal lamina to the apical junctional complexes. The luminal cell pole exhibits some short microvilli and forms irregularly shaped, glycogen containing protrusions. Within the cytoplasm of the gland cells numerous spherical mitochondria, some dense bodies, a typical Golgi apparatus, free ribosomes and a poorly developed endoplasmic reticulum are to be observed. Secretory granules which can be grouped into three types on the basis of their electron density occur in the supranuclear regions of most of the cells. According to histochemical tests all granules contain a periodate reactive sialomucin and some of them also sulfate groups. The glandular parenchyma is site of an exceptionally strong unspecific esterase activity and is rich in β-D-glucuronidase, β-D-glactosidase, aldolase, α-glycerophosphate dehydrogenase, lactate dehydrogenase, alcohol dehydrogenase, NAD-dependent isocitrate dehydrogenase, succinate dehydrogenase and cytochrome oxydase.
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 1 (1969) 
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
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  • 30
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    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 1 (1969), S. 1-2 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    International Journal for Numerical Methods in Engineering 1 (1969), S. 3-28 
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    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: Finite element methods can be formulated from the variational principles in solid mechanics by relaxing the continuity requirements along the interelement boundaries. The combination of different variational principles and different boundary continuity conditions yields numerous types of approximate methods. This paper reviews and reinterprets the existing finite element methods and indicates other alternative schemes. Plate bending problems are used to compare the relative merits of the various methods.
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    International Journal for Numerical Methods in Engineering 1 (1969), S. 47-66 
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    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: Three methods for finding natural frequencies and modes of complex structures composed of beam elements are described and compared. The analysis is extended to include hysteretic damping for the determination of response and transmissibility without a modal analysis. Experimental comparison is given for the response of a simple engineering structure.
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    International Journal for Numerical Methods in Engineering 1 (1969), S. 29-45 
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    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: The theory, function generator routine and testing procedures are given for a six-node 18 degree of freedom triangular element. At corner nodes the variables are the displacement and the two slopes. At midside nodes the variables are the displacement, the slope normal to the side, and the rate of change of this along the side - i.e., the rate of torsion. Of two options, one divides the triangle into three and takes different quartic displacements in the three regions, and the other uses displacement functions with singularities at the vertices. According to a test which compares the energies of the two formulations by eigenvalues, the second is the better if the integration is accurate. The same test, together with others based on finite differences and on nodal values, etc. checks the correctness of the routine decisively.
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    International Journal for Numerical Methods in Engineering 1 (1969), S. 67-73 
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    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: Finite difference treatment of two-dimensional problems in elastostatics is usually based on the differential equations for the displacement vector or the Airy stress function, depending on whether boundary conditions are on displacement or stress. In either case, determination of stresses requires numerical differentiation and therefore use of a rather fine grid. Moreover, neither method is suited to the treatment of mixed boundary conditions. The alternative method developed in this paper uses the first derivatives of the displacement components at the grid points as basic variables and hence does not require numerical differentiation in the evaluation of stresses. Appropriate finite difference equations are established, and their use is discussed in connection with a specific example with known explicit solution.
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    International Journal for Numerical Methods in Engineering 1 (1969) 
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    International Journal for Numerical Methods in Engineering 1 (1969), S. 279-299 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: When calculating complex interconnected systems (electrical, power, water supply, gas systems, etc.) by digital computer, a number of common problems arise, connected both with the mathematically correct formulation of the problem under investigation, and with the algorithms of the solution, the programming of which makes it possible to reduce the computing time, the store capacity and the volume of input data required. The present article is devoted to the solution of these problems. The procedure is illustrated by formulating and manipulating the equations relating to complex interconnected mine ventilation networks.
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    International Journal for Numerical Methods in Engineering 1 (1969), S. 301-310 
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    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: Solution of plane elastic problems by piecewise linear approximation is outlined. This method is based upon Galerkin error distribution technique, which leads to simultaneous algebraic equations identical to those associated with the Finite Element Method. In addition, this method permits definition of the discretization error, which can be computed once the displacement components are known. Properties of the interpolation functions are discussed, and a sequence of internally compatible plane elastic elements is defined.
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    International Journal for Numerical Methods in Engineering 1 (1969), S. 311-331 
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    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: A review is given of some mathematical programming methods suitable for optimization of structures needing matrix methods for analysis. An application is presented for elastic flat grillages made of straight orthogonal beams normally loaded. Empirical relationships are used to relate beam section properties so that each beam element has only one design variable. Optimization results are obtained by methods of stress-ratio, linear programming-cutting plane and usable-feasible gradient directions. A comparison of the efficiency of these methods is given for the grillage designs which are shown to have non-convex stress constraints and numerous relative optima. Instances are given of non-fully stressed global optima and fully stressed designs which are not local optima for cases with only stress constraints. Discussions include locating the global optima for grillage designs and extensions of the methods presented to other structural design problems.
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    International Journal for Numerical Methods in Engineering 1 (1969), S. 379-394 
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    Notes: A completely numerical method for steady state linear viscoelastic stress analysis is presented by means of the finite element approach. Numerical representations of the measured viscoelastic constitutive relations are used. This method is developed to obtain steady state solutions to mixed boundary value problems in which the character of the boundary conditions at a point changes with time. Such problems cannot be handled by direct application of the correspondence theorem. A numerical example of viscoelastic sheet rolling is presented along with an experimental verification of the solution by photo-viscoelastic observations.
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    International Journal for Numerical Methods in Engineering 1 (1969), S. 351-378 
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    Notes: The application of non-linear programming methods for the optimum design of statically indeterminate structures is discussed, with special emphasis on the design of elastic grillages loaded laterally and in plane. Some features of SUMT (sequential unconstrained minimization technique) are demonstrated by means of numerous examples of varying complexity. The Variable Metric method of search is discussed and compared to Powell's Direct Method. It is shown that non-convex sets of design variables are often encountered in structural problems of the grillage type. SUMT may still be used, but the choice of starting value and initial response factor decisively influences the chance of finding the global optimum.It is demonstrated that a fully stressed design may not necessarily correspond to the minimum weight design. Optimum design of grillages which are simultaneously subjected to lateral and in-plane loads may be performed efficiently by means of non-linear programming.
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    International Journal for Numerical Methods in Engineering 1 (1969), S. 395-395 
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    International Journal for Numerical Methods in Engineering 1 (1969), S. 275-277 
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    Source: Wiley InterScience Backfile Collection 1832-2000
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    International Journal for Numerical Methods in Engineering 1 (1969), S. 75-100 
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    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: The paper presents first a general formulation of the elasto-plastic matrix for evaluating stress increments from those of stresses for any yield surface with an associated flow rule. A new ‘initial stress’ computational process is proposed which is shown (1) to yield more rapid convergence than alternative approaches (2) to permit large load increments without violating the yield criteria and thus simply to establish lower bound solutions. Several solutions showing stress distribution, strain development and growth of plastic enclaves are given both for the von Mises and for Coulomb (Drucker) type yield surfaces. Load reversal and thermoplastic behaviour are dealt with.
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    International Journal for Numerical Methods in Engineering 1 (1969), S. 135-149 
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    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: The assumed stress distribution approach is used to derive the stiffness matrix of a plate-bending element of general polygonal shape having any number of nodes. The effect of assuming various numbers of unknown coefficients in the stress distributions is examined and the convergence properties of the resulting elements compared with others derived form assumed displacements.
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    International Journal for Numerical Methods in Engineering 1 (1969), S. 163-167 
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    Notes: Deformation functions which, in addition to satisfying the continuity conditions at nodes. Also satisfy. Approximately, the governing differential equation within the element allow system eigenvalues to be found more accurately, with a given number of elements, than is possible with previously published deformation functions. This is illustrated for the case of beams.
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    International Journal for Numerical Methods in Engineering 1 (1969), S. 169-175 
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    Notes: A numerical method for obtaining the Green's functions for Laplace's, Poisson's, and the transient heat diffusion equations is presented. The Green's functions thus obtained are then employed to rapidly obtain numerical solutions of the above equations by matrix multiplication, with subsequent considerable savings in machine time.
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  • 47
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    International Journal for Numerical Methods in Engineering 1 (1969), S. 151-162 
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    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: The direct Finite Element Analysis which was successfully employed in the solution of dynamic flexural traveling wave problems is extended herein to provide the transient behaviour of finite beams and plates in which shear deformation and rotatory inertia are considered. The particle and angular velocities are exponentially damped so that the static solutions for these problems are obtained with the same analysis which provided the dynamic and transient cases. Three special cases are chosen as examples. In the first, a sinusoidally varying shear force is applied at the tip of a cantilever beam. The resonant characteristics of this beam for both the undamped and damped cases are studied. In the second, a step shear loading is applied to a cantilever beam and its damped dynamic history is studied. Finally, a circular plate whose outer edge is simply supported is impacted at its inner edge by a step moment and its damped transient behaviour is determined. The idea of the methods is potentially applicable to dynamic problems in general.
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    International Journal for Numerical Methods in Engineering 1 (1969), S. 177-180 
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    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: The solution of the large numbers of non-linear algebraic equations occurring in analyses of non-linear structural systems using finite differences or finite elements is time consuming even for the fastest computers. This paper presents a method of solution based on a Taylor's expansion technique which is an aid in the solution of such systems of equations.Examples presented show that in the finite element analysis of moderately non-linear structural systems the technique provides sufficiently accurate solutions. For more non-linear systems the technique provides excellent starting values for the Newton-Raphson method.
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    International Journal for Numerical Methods in Engineering 1 (1969), S. 201-203 
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    International Journal for Numerical Methods in Engineering 1 (1969), S. 181-200 
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    Notes: Surface displacements at the end of a semi-infinite, circular cylinder due to an axisymmetric ring of forces on the end are examined. The solution which has been found may then be used to find surface displacements for general axisymmetric loadings by convolution. The solution, in tabular form, is given as corrections to the counter-part half-space solution.The method of solution involves a three step superposition process. First, the displacement due to a ring of forces on a half-space is found by using the Boussinesq solution. Then, the excess tractions on the half-space, over that of the cylinder, are removed. This is done in two parts. The problem of an infinite cylinder with linearly varying pressure and shear over a short length of the lateral surface is solved by using Fourier integrals. This is used for the removal of the pressure and shear on the lateral surface of the cylinder by convolution. Next, the stresses at the mid-section of the infinite cylinder are removed. This is done by finding a set of boundary conditions for the end which yields zero tractions on the lateral surface. Then a series of these boundary conditions is used to approximate the tractions which must be removed.With the solution thus obtained, two sample problems are shown: 1. an elastic cylinder in contact with a half-space; 2. a rigid punch in contact with an elastic cylinder.
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    International Journal for Numerical Methods in Engineering 1 (1969) 
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    International Journal for Numerical Methods in Engineering 1 (1969), S. 205-221 
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    Source: Wiley InterScience Backfile Collection 1832-2000
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    Notes: This paper presents a general theory of finite elements. The concept of finite elements is cast in a general topological framework valid for spaces of finite dimension. It is shown that the idea of finite element models can be developed in higher-dimensional spaces, independent of specific co-ordinate systems, for any type of continuous abstract function defined on the space. Generalizations of the familiar Lagrange and Hermite interpolation functions are presented as well as a general statement of the notion of generalized variables and conjugate fields. It is also shown that admissible finite elements can be developed for non-Euclidean spaces of finite dimension. Topological properties of finite element models are examined in Part I of the paper. Part II is devoted to certain applications.
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    International Journal for Numerical Methods in Engineering 1 (1969), S. 224-224 
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    International Journal for Numerical Methods in Engineering 1 (1969), S. 247-259 
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    Notes: In Part I of the this paper, topological properties of finite element models of functions defined on spaces of finite dimension were examined. In this part, a number of applications of the general theory are presented. These include the generation of finite element models in the time domain and certain problems in wave propagation, kinetic theory of gases, non-linear partial differential equations, non-linear continuum mechanics, and fluid dynamics.
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    International Journal for Numerical Methods in Engineering 1 (1969), S. 225-245 
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    Notes: A method is presented based on matrix algebra for the dynamic analysis of a mixed rotating and non-rotating vibration system. Such systems occur in practice when turbo-alternator sets are mounted on flexible steel foundations.The mathematical model considered consists of a rotating non-uniform, bi-symmetric shaft connected via three or more flexible-film bearings to a flexible structure throughout which mass is distributed. The shaft, which is assumed to rotate at constant speed, is heavy, flexible and carries several rigid axi-symmetric discs. Viscous damping is assumed to act in all parts of the system and gravitational effects are ignored.
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    International Journal for Numerical Methods in Engineering 1 (1969), S. 261-274 
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    Notes: A presentation is made of a rectangular plate bending element, the use of which corresponds to the finite difference method. The element stiffness matrix is arrived at by approximation of the strain energy of the element by suitably selected finite difference expressions which contain not only values in respect of the deflection, but also values of its first derivatives. On the basis of the connection found between the two methods, some changes are suggested in the finite difference method, which involve a more realistic way of considering the detailed distribution of the loading. The effect of these modifications is illustrated in two applications.
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    International Journal for Numerical Methods in Engineering 1 (1969), S. 101-122 
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    Notes: The derivation of the stiffness matrix for a refined, fully compatible triangular plate bending finite element is presented. The Kirchhoff plate bending theory is assumed. Six parameters or degrees of freedom are introduced at each of the three corner nodes resulting in an 18 degree of freedom element. This refined element is found to give better results for displacements and particularly for internal moments than any plate bending element, regardless of shape, previously reported in the literature.
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    International Journal for Numerical Methods in Engineering 1 (1969), S. 123-133 
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    Notes: The large deflection problem of a rectangular plate is analysed by using the finite element method and employing the iteration technique. In the present study, the stiffness matrix of a rectangular plate element for bending proposed by Greene is employed, and results of numerical examples duly justifies applicability of the present method.
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    International Journal for Numerical Methods in Engineering 1 (1969) 
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    International Journal for Numerical Methods in Engineering 1 (1969), S. 333-349 
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    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The paper presents a method for reducing the size of a vibration analysis by generating an inertia matrix referred to a limited set of ‘master’ vibrational freedoms. In designing a computer program to perform this mass condensation process, the emphasis has been on providing a two way interface between structural analysis and vibration analysis programs. The transformation from the full set of degrees of freedom to the master set makes extensive vibration calculations economically feasible giving solutions in terms of the amplitudes of the master freedoms. However, by reversing the transformation after completion of a vibration analysis, it is possible to restore the full set of freedoms, allowing automatic plotting of mode shapes in full detail, and re-entry to the structural analysis program for the purpose of computing dynamic stresses.A worked example is given. This is a realistic machine tool structure rather than the simple plates or beams which are usually used for illustration purposes. Natural frequencies and mode shapes, calculated with various degrees of condensation, are compared with those obtained by using all possible freedoms. A comparison is also made with an intuitive selection of ‘lumped masses’.
    Additional Material: 9 Ill.
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  • 61
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    Anatomy and embryology 127 (1968), S. 138-144 
    ISSN: 1432-0568
    Keywords: Capillary density ; Postnatal development ; Corpus callosum ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An Paraffinschnitten durch das Corpus callosum perfusionsfixierter Gehirne von 19 Katzen im Alter von einem Tag bis zu 2 1/2 Jahren wurde das Capillarvolumen bestimmt. Es beträgt bei der neugeborenen Katze 0,81 Vol.-%. In der 2. Lebenswoche beginnt eine Zunahme, die in der 5. Woche ein Maximum von 2,92 Vol.-% erreicht. Im Verlauf der 6. Woche setzt eine zunächst rasche, von der 7. Woche an aber nur noch langsam verlaufende Abnahme ein, bis bei einem Lebensalter von etwa 1 Jahr ein für das erwachsene Tier charakteristischer Wert um 1,5 Vol.-% erreicht wird. Die Abnahme des Capillarvolumens hängt mit der Markscheidenbildung und der dadurch bedingten Zunahme des Fasermaterials zusammen.
    Notes: Summary Postnatal changes of capillary density have been determined in paraffin sections through the corpus callosum of 19 cats. At birth the capillary density amounts to 0.81 vol.-%. In the 2nd week of postnatal life it begins to increase and reaches a maximum of 2.92 vol.-% in the 5th week. From the 6th week onwards there is an initially steep and later on less pronounced decrease until at an age of about 1 year a value of about 1.5 vol.-% is reached, which is maintained in adult life. — The decrease in the percentage of capillary volume seen after the 5th week is caused by the rapid increase in fibrous material due to myelination.
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  • 62
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    Anatomy and embryology 127 (1968), S. 221-231 
    ISSN: 1432-0568
    Keywords: Marginal glia ; Superficial nerve cells ; Brain stem ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An Paraffinschnitten durch perfusionsfixierte Gehirne von erwachsenen Katzen werden in der Glia marginalis des Hirnstamms unterschiedlich gebaute Bezirke beschrieben. Es wird gezeigt, daß über dem Nucleus paragigantocellularis und über dem Ncl. “z” swischen den Fasern der Glia marginalis Nervenzellen liegen. Über dem erstgenannten Kern stellen diese Zellen möglicherweise das morphologische Substrat der chemosensiblen Felder dar, die durch die physiologischen Untersuchungen von Loeschcke, Mitchell u.a. bekannt geworden sind.
    Notes: Summary In the marginal glia covering the brain stem of the cat, regional differences are described in paraffin sections of brains which had been fixed by perfusion of Bouin's fluid. It is shown that between the glia fibres covering the nucleus paragigantocellularis and the nucleus “z” there are nerve cells. It is suggested that in the region of the nucleus paragiganto-cellularis these cells are the morphological substrate of a chemosensible zone described in physiological experiments by Loeschcke, Mitchell and others.
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  • 63
    ISSN: 1432-0533
    Keywords: Alumina Cream ; Intracerebral Injection ; Pathology of Growing Brain ; Myelination ; Demyelination ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zum Studium der Reaktion des jugendlichen und erwachsenen Gehirnes auf einen chronischen Reiz wurden bei Katzen verschiedenen Lebensalters intracerebrale Injektionen von Aluminiumhydroxyd vorgenommen. Die Tiere wurden nach Überlebenszeiten von 7 Tagen, 40 Tagen und 3 Monaten durch Perfusion mit Bouinscher Lösung getötet. Die histologische Untersuchung der Gehirne ergab eine Reihe von Unterschieden, je nachdem ob die Injektion vor oder nach der Markscheidenbildung erfolgt war. Besonders auffällig war der Befund, daß in der noch unmyelinisierten weißen Substanz jugendlicher Tiere kein Hirnödem und keine Gliose auftritt. Obgleich durch fluorescenzmikroskopische Untersuchungen gezeigt werden konnte, daß das Aluminium von der Injektionsstelle aus weit in das umgebende Hirngewebe eindringt und dort über lange Zeit festgehalten wird, werden bei den jungen Tieren die Markscheiden später bis in die unmittelbare Umgebung des Herdes normal angelegt. Bei erwachsenen Tieren kam es dagegen in der Nachbarschaft des Herdes stets zu einem starkem Ödem der weißen Substanz, zum Zerfall der Markscheiden und zu einer ausgebreiteten Gliose. Weitere Unterschiede in der Reaktionsweise des Gehirnes jugendlicher und erwachsener Tiere, die den Cortex und insbesondere die marginale Gliafaserschicht betreffen, werden im einzelnen beschrieben und diskutiert.
    Notes: Summary In order to compare the reaction to chronic irritation of young and adult brain intracerebral injections of alumina cream were made in cats of various ages. The animals were killed by perfusion with Bouin's fluid after a survival time of 7 days, 40 days, and 3 months. Histological investigation revealed gross differences in the reaction according to whether the intracerebral injections had been made before or after myelination. Particularly striking was the finding that in the non-myelinated white matter of young animals there was no edema and no subsequent gliosis. Although alumina, as evidenced by fluorescence microscopy after staining with Morin, spreads into the tissue surrounding the focus, subsequent myelination appeared to be normal even in regions close to the site of injection. In contrast, injection into the brains of adult animals was followed by edema, widespread demyelination and gliosis of the white matter near the site of injection. Further differences between young and adult animals were found in the reaction of the grey matter and particularly of the marginal glia.
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  • 64
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    Experimental brain research 5 (1968), S. 153-172 
    ISSN: 1432-1106
    Keywords: SII ; Thalamus ; Cat ; Somatotopical localization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The corticothalamic projection from the anterior ectosylvian gyrus in the cat has been studied with the silver impregnation method of Nauta. The second somatosensory cortical area (SII) projects upon the ipsilateral nucleus ventralis posterolateralis (VPL), nucleus ventralis posteromedialis (VPM), the posterior thalamic region (PO) and to a slight extent upon the reticular nucleus of the thalamus (R), the centrum medianum (CM), the parvocellular part of VPM (VPMpc) and the nucleus ventralis posterior inferior (VPI). A somatotopical arrangement in the projection upon the ventro-basal (VB) complex has been demonstrated and a topical arrangement in the corticothalamic fibers from SII to PO is also evident. The transitional area between SII and the second auditory cortex sends fibers mainly to the entire magnocellular part of the medial geniculate body (MGmc) and to a lesser degree to the principal division of this nucleus (MGp). The corticofugal fibers from SII follow various and rather complicated circuitous routes before they end in the different thalamic nuclei. The experimental findings are discussed in the light of recent anatomical and physiological observations. It is shown that zones B and C of SII which have been shown by Carreras and Andersson (1963) to possess a large number of place and modality specific neurons project upon the VB-complex. On the other hand, zone A which contains a majority of place and modality unspecific neurons sends its fibers exclusively to PO. Finally the problem of thalamocortical projections to SII is briefly discussed.
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  • 65
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    Experimental brain research 5 (1968), S. 326-340 
    ISSN: 1432-1106
    Keywords: Subcellular fractionation ; Parallel fiber axons ; Cerebellum ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fractionation of the cat cerebellum has revealed that the parallel fibers of the cerebellar cortex break into two types of fragments which can be recognized in thin sections and in suspensions of negatively stained material. Fragmented material correlates well with electron micrographs of parallel fibers in situ. Parallel fiber axons and their bulbous presynaptic expansions sediment mainly into two subfractions. One unique layer consists of the intersynaptic tubular pieces of parallel fiber axons. Another layer is enriched in the synaptic portions which make contact with Purkinje spines. The possible contaminants of these fractions are discussed. These fractions may permit analysis of the chemical organization of conducting vis à vis synaptic membranes from a known anatomical source. This material was presented as a preliminary report at the Sixth Annual Meeting of the American Society for Cell Biology, November 1966, and is contained in J. Cell. Biol. 31, 52A, 1966.
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  • 66
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    Experimental brain research 6 (1968), S. 234-246 
    ISSN: 1432-1106
    Keywords: Tactile discrimination ; Dorsal column-medial lemniscus ; Spino-cervico-thalamic tract ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The role of two spinal sensory pathways, the dorsal column (DC) pathway and the spino-cervico-thalamic tract (SCTT), involved in tactile discrimination was studied. Pour lesion groups of cats (DC lesion, SCTT lesion, combined DC and SCTT lesion, and sham-operated) were tested to discriminate various degrees of roughness. Animals with either the SCTT or the combined lesions performed at around 50–60% level under all the conditions tested. On the other hand, those with the DC lesion and sham-operations generally attained 80–100% level of performance. A difference between the DC group and sham-operated group was found in their rate of learning and ability for finer discrimination. These results are interpreted as an indication that a duplicity in transmission of tactile sensation exists, the DC pathway being more specific than the SCTT.
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  • 67
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    Experimental brain research 5 (1968), S. 55-60 
    ISSN: 1432-1106
    Keywords: EEG frequency ; Regional cortical blood flow ; Isotope measurements ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The EEG frequency content in cats, anaesthetized by Nembutal and artificially ventilated, was altered by means of injections of either additional Nembutal or of Metrazol. The EEG in cerveau isolé preparations was also changed in the same way. The regional cortical blood flow was determined by means of the 85Krypton technique. A high correlation was found between the frequency content of the EEG, measured by means of manual frequency analysis, and the regional cortical blood flow. The cortical blood flow increased when the mean frequency increased, and vice versa. A similar correlation was found when the EEG mean frequency was changed by means of sensory stimulation.
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  • 68
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    Experimental brain research 4 (1968), S. 321-329 
    ISSN: 1432-1106
    Keywords: Temperature ; Interval histograms ; Optic nerve ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In 13 Katzen wurde die Aktivität von 128 Einzelfasern des N. opticus bei Temperaturen zwischen 27 und 39° C abgeleitet und direkt einer Intervallanalyse zugeführt. Die Durchschnittsfrequenz sank mit abnehmender Temperatur von 56/sec bei 39–37° C auf 21/sec unter 29° C. Bei Temperaturen über 35° C wurden nur unimodale oder zweigipfelige Verteilungen mit gehäuften Mehrfachentladungen gefunden. Unter 35° C traten multimodale Intervallhistogramme und Übergangstypen auf, bei denen einer Verteilung mehrere Gipfel aufgesetzt erschienen. Unter 29° C wurden nur mehrgipfelige Verteilungen beobachtet. In der phasischen Reaktion der Neurone wurden mit der Temperaturabnahme Latenzen länger und Hemmungen stärker. Unter 30° C konnte der Reaktionstyp des Neurons oft nicht mehr erkannt werden. Das vermehrte Auftreten multimodaler Verteilungen bei niedrigen Temperaturen ließe sich durch Verminderung von Interaktionen in der Retina erklären. Die Anregung zu dieser Untersuchung wurde von Herrn Professor Dr. Hans Bornschein gegeben.
    Notes: Summary The activity of 128 single fibers of the optic nerve was recorded in 13 cats at temperatures between 27 and 39° C. Nonsequential interval histograms were computed on line. Decreasing temperature diminished the mean frequency of the fiber activity from 56/sec at 37–39° C to 21/sec below 29° C. Above 35° C the histograms were unimodal or bimodal, the first peak caused by repetitive discharges. Below 35° C multimodal histograms appeared; in some distributions several peaks were superimposed. At temperatures below 29° C only multimodal distributions were obtained. The phasic response of the neurons to light showed an increase of latency and of inhibition according to the decrease of temperature. Often the type of the response of the neuron could not be recognized below 30° C. During hypothermia interactions in the retina may be reduced and this may explain why multimodal distributions occur more frequently.
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    Experimental brain research 5 (1968), S. 61-71 
    ISSN: 1432-1106
    Keywords: EEG frequency ; Regional cortical blood flow ; Isotope measurements ; Effects of hypoxia ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The relationship between cortical blood flow and the frequency content of the EEG was studied in a circumscribed area of the exposed cerebral cortex in cats under nitrous oxide-oxygen anaesthesia. Autoregulation of the cortical blood flow was also tested during step-changes of the arterial blood pressure. Observations were made before and after an episode of severe hypoxia. 2. An episode of systemic hypoxia disrupted the normal high correlation between cortical blood flow and EEG frequency content. In the post-hypoxic period cortical flows of up to about three times normal values were recorded together with brain swelling and a slow wave EEG. The hyperemia and swelling subsided during 1–2 h after the hypoxic episode, and were accompanied by partial or complete recovery of the EEG. In the post-hypoxic period a defective autoregulation of the cortical blood flow to changes in the systemic blood pressure was demonstrated. 3. The cerebral post-hypoxic state with hyperaemia, brain swelling, EEG depression, and loss of autoregulation of blood flow, is probably caused by an accumulation of anaerobic metabolites which lead to cerebral tissue acidosis.
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  • 70
    ISSN: 1432-1106
    Keywords: Cerebral cortex ; Thalamus ; Cat ; Nauta
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The corticothalamic projections from the gyrus proreus and the medial wall of the rostral hemisphere have been studied in the cat with the silver method of Nauta. The gyrus proreus projects upon the following nuclei (for abbreviations, see list on page 133), ipsilateral R, VA, VM, VL, MD, Pc, CL, CM, Pf, VPM, VPMpc. VPI and to the contralateral principal nucleus of the trigeminal nerve. The medial wall of the rostral hemisphere projects bilaterally upon R, VA, VM, VL, MD, Pc, CL, CM, Pf, VPM, VPMpc, VPI, VPL, the dorsal column nuclei and the principal nucleus of the trigeminal nerve. The ipsilateral thalamic projection is more abundant than the contralateral. The latter appears to increase in amount as the lesion is placed successively more ventrally on the medial wall of the rostral hemisphere. Some degenerating fibers cross in the corpus callosum and descend in the contralateral internal capsule but the majority cross in the dorsal part of the anterior commissure and reach the medial aspect of the anterior limb of the contralateral internal capsule. A somatotopical organization of the medial wall of the rostral hemisphere has been demonstrated. The rostrocaudal part projects upon the ipsilateral VPL lateralis (VPLl) and nucleus cuneatus and the contralateral nucleus gracilis and VPL medialis (VPLm). The caudal part of this cortical area sends fibers bilaterally to VPM, VPMpc, and the principal nucleus of the trigeminal nerve. The intermediate part, which also includes agranular cortex on the medial wall, projects upon ispsilateral VPLm and nucleus gracilis and upon contralateral VPLl and nucleus cuneatus. — The fibers to the ventro-basal complex, dorsal column nuclei and the principal nucleus of the trigeminal nerve are rather thick. The corticofugal fibers to the other thalamic nuclei are quite thin. — The findings are discussed in light of relevant anatomical and physiological observations in the literature and special emphasis has been laid on reported observations on the “supplementary motor” area.
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    Experimental brain research 5 (1968), S. 210-234 
    ISSN: 1432-1106
    Keywords: Sensorimotor cortex ; Pontine nuclei ; Somatotopical localization ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Small lesions (in some cases bilateral) were made in the cerebral primary sensorimotor region in altogether 21 adult cats and the ensuing degeneration in the pontine nuclei was studied with the silver impregnation methods of Nauta and Glees. Using thermocoagulation it was possible to obtain lesions restricted entirely to particular cortical regions (for example the “hindlimb region” in the posterior sigmoid gyrus). The main results are as follows: 1. All parts of the primary sensorimotor region send fibres to the pontine nuclei. The projections from the posterior part of the posterior sigmoid gyrus and the posterior part of the coronal gyrus are relatively scanty. 2. The cortical “motor” area (the anterior sigmoid gyrus and the anterior part of the coronal gyrus) and the “sensory” area (the posterior sigmoid gyrus and the posterior part of the coronal gyrus) do not project to identical pontine regions, although both projections are organized in principally the same way. 3. The “motor” and “sensory” areas both project in a somatotopical manner onto two longitudinally oriented sharply delimited columns. In both projections one column is located medial and one lateral to the longitudinal fibre bundles of the corticospinal and corticobulbar tracts. Within the medial columns the “hindlimb” is represented ventrally with “face” most dorsally, within the lateral columns the “hindlimb” is located most caudally, with “forelimb” and “face” successively more rostrally. 4. The present results are in agreement with physiological observations on the cerebrocerebellar relations, but show that the pontine projection from the primary sensorimotor cortex is organized in a more complex manner than hitherto assumed.
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  • 72
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    European archives of psychiatry and clinical neuroscience 211 (1968), S. 43-62 
    ISSN: 1433-8491
    Keywords: Neuronal activity ; EEG-cortex ; Hypoglycemia ; Cat ; Neuronale Aktivität ; EEG-Cortex ; Hypoglykämie ; Katze
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. An Katzen wurden EEG-Veränderungen durch Hypoglykämie hervorgerufen und mit den Aktivitätsveränderungen corticaler Neurone verglichen, wie sie sich bei intracellulären und „quasi-intracellulären“ Ableitungen darstellen. Es zeigte sich, daß pathologische EEG-Veränderungen erst bei niedrigen Blutzuckerwerten (zwischen 30 und 25 mg-%) auftreten und daß es erst bei Werten unter 10–15 mg-% zur elektrischen Stille kommt. 2. Während des flachen, desynchronisierten EEG des wachen Hirns vor Hypoglykämie lassen sich keine Beziehungen zwischen den kleinen EEG- und statistisch verteilten Zellpotentialen nachweisen. — Während der regelmäßigen 8–10/sec- Spindelgruppen, die bei tiefer Hypoglykämie häufig zu beobachten sind, findet sich eine enge Korrelation zwischen den einzelnen Oberflächen-negativen Spindelwellen und Zelldepolarisationen, die meist unterschwellig sind. 3. Bei den langsamen Wellen der δ-Frequenz finden sich ähnliche, aber weniger enge Korrelationen für die flachen, „monomorphen“ δ-Wellen. Andere Formen von langsamen Potentialkomplexen des Cortiocogramms, die im Tintenschreiber als „polymorphe“ δ-Wellen imponieren können, zeigen etwas andere, aber für den einzelnen Wellenkomplex jeweils konstante Beziehungen zur Zellaktivität. 4. Die steilen Wellen wurden unterteilt in primär positive und in primär negative bi- (oder auch tri-)phasische Potentiale. Die primäre Phase der primär-positiven steilen Potentiale ist im Durchschnitt kürzer (unter 20–40 msec) als die negative Phase der primär-negativen Phase (über 100 msec). Die meist überschwellige Zelldepolarisation, die in der Regel zu einer kurzen Gruppenentladung führt, fällt mit der primären Phase, also entweder der positiven oder der negativen zusammen. Die Phasenkoppelung, d. h. die „Synchronisation“ mit dem EEG-Potential, ist jedoch im Fall der primär-positiven Phase enger und die Dauer der Depolarisation kürzer als im Fall der primär-negativen steilen Potentiale. Diese Befunde werden als Hinweis auf eine stärkere Synchronisation der Aktivität der corticalen Nervenzellpopulation im Fall der primär-positiven steilen Potentiale gewertet. 5. Die verschieden engen Phasenkoppelungen und die je nach Steilheit der Wellen wechselnden Phasenbeziehungen zwischen Zellaktivierung und oberflächennegativen resp. -positiven Potentialen werden an Hand eines einfachen Modells der Elektrogenese von EEG-Potentialen erklärt, das den Synchronisationsgrad cortico-petaler und cortico-fugaler Faseraktivität sowie die Summation postsynaptischer Potentiale corticaler Neurone berücksichtigt.
    Notes: Summary 1. The EEG, recorded monopolarly from the pial surface, was investigated during insuline induced hypoglycemia in acute cats and compared with the activity of cortical cells recorded with intra or “quasi-intracellular” electrodes. 2. Pathological changes of the EEG were observed only when the blood glucose fell below 25–30 mg-%. Electrical silence was observed at blood glucose levels below 15–10 mg-%. 3. The essentially flat, “desynchronized” EEG of the awake animal before hypoglycemia did not show any relation between the small, irregular fast EEG- potentials and the statistically distributed cellular potentials. —During the regular 8–10/sec spindles (Fig. 3) a close correlation was found between the single surface- negative spindle waves and the mostly subthreshold compound cellular EPSP's. 4. Slow waves of δ-frequency showed similar but less close correlations, if the waves were of regular appearance comparable to “monomorphic” δ-waves (Fig.4A). Other forms of slow complex potentials (Fig.4B and C), which correspond to “polymorphic” δ-waves in an EEG-record (e.g. Fig.4C and Fig.2d) may show different relations between cellular and EEG-activity which were, however, consistent for each type of complex wave. 5. Sharp waves were divided into primary positive and primary negative bi- (or tri-)phasic potentials. The primary positive phase was always shorter (below 20–40 msec) than the primary negative phase (above 100 msec). The mostly suprathreshold cellular depolarization, which may lead to a short burst of discharge, coincided with the primary, i.e. either the primary positive or the primary negative phase (Fig. 7 shows records from the same cell and different EEG-phenomena). The phase coupling, i.e. the “synchronization” with the EEG-potential, is closer in the primary positive than the primary negative waves, and the duration of the cellular depolarization is also shorter in the former case (compare Fig.7B I–III with 7B IV). This can be interpreted as stronger synchronization of cellular activity during the short primary positive waves. 6. A causal relation between cortical neuronal activity and EEG-potentials is assumed. Differences in the closeness of phase coupling and the changing phase relation between cellular and EEG-activity according to the form and steepness of cortical EEG-potentials are explained by a simple model of electrogenesis of EEG-potentials, which takes in account the degree of synchronization of corticopetal and cortico-fugal fibre activity as well as the summation of postsynaptic potentials of cortical neurones.
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    European archives of psychiatry and clinical neuroscience 211 (1968), S. 155-169 
    ISSN: 1433-8491
    Keywords: Sleep EEG ; Experimental Epilepsy ; Cat ; Schlaf-EEG ; Experimentelle Epilepsie ; Katze
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Frage der Wacho- der Schlaf-Aktivierung der fokalen Epilepsien wird bei 20 epileptischen Katzen im chronischen Experiment untersucht (Kopeloff-Methode). Die Narben wurden im Nucleus amygdaloideus (Pars basolateralis), Hippocampus dorsalis, Formatio reticularis mesencephali, Isocortex gesetzt. Bei einer Untersuchungsdauer der einzelnen Tiere zwischen 3 und 60 Tagen, wurden insgesamt 442 Std in Polygraphie (EEG, EMG, Augenbewegungen) abgeleitet. Die Tiere zeigten innerhalb der ersten 7 Tage Krampfpotentiale im EEG und die meisten ab der 2. Woche Krampfanfälle. Bei Katzen mit subcorticalen Narben war keine Veränderung der Dauer, der Verteilung und der Organisation der einzelnen Schlafstadien nachweisbar. Die im Ruhe-EEG vorhandenen Paroxysmen wurden während des langsamen Schlafes nicht aktiviert und fokalisiert. Im paradoxen Schlaf waren die Krampfpotentiale völlig desaktiviert, es traten einzelne Spindeln auf. Die Tiere mit Narben im Isocortex zeigten im langsamen Schlaf seltene Paroxysmen. Während der häufigeren kurzen Phasen des paradoxen Schlafes war eine Fokalisierung der Spitzen im Bereich der Läsion nachweisbar, jedoch, keine Aktivierung. Bei allen Tieren war die ausgeprägteste Aktivierung der Krampfbereitschft stets in dem von uns als „Wach mit motorischer Inaktivität“ bezeichnete Phase zu bemerken. Daher wird angenommen, daß dieser Zustand bei der Katze mit dem Einschlafstadium des Menschen vergleichbar ist.
    Notes: Summary The activation of focal epileptic activities during wakefulness, slow and REM sleep was studied in chronic experiments in 20 epileptic cats (Kopeloff's method). The lesions were produced in the nucleus amygdaloideus (pars basolateralis), hippocampus dorsalis, formatio reticularis mesencephali and in the isocortex. Each animal was observed from between 3 to 60 days and a total of 442 hours of polygraphy (E.E.G., E.M.G, Eye movements) were recorded. Within the first 7 days all animals showed E.E.G paroxysms and most of them showed seizures from the beginning of the second week. In those cats with subcortical lesions there was no change detected in the duration, distribution and organisation of the different sleep phases. The paroxysmal E.E.G activity seen in the wakeful animal were not activated or focalised during slow-wave sleep; in REM sleep the paroxysms disappeared completely, only a few spindles were seen. Animals with lesions in the isocortex rarely showed paroxysms during the slow wave sleep. However, during REM sleep a clear focalisation was seen, although there was no additional activation in the area of the lesion. In all animals the most significant of the paroxysms was seen during a state which we should like to describe as; “Awake without any motor activity”. It is assumed that this state corresponds to the state of falling asleep in man.
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  • 74
    ISSN: 1432-2013
    Keywords: Cat ; Electrophysiology ; Single Units ; Bulbar Trigeminal Nuclei ; Katze ; Elektrophysiologie ; Einzelneurone ; Bulbäre Trigeminuskerne
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. Funktionelle Eigenschaften der excitatorischen Verbindungen von Cortex, Thalamus und Peripherie zu 438 Neuronen der bulbären Trigeminuskerne wurden untersucht. Es konnten Beziehungen zwischen den Latenzzeiten der Antworten auf ipsilaterale, periphere Einzelreize, contralaterale thalamische Einzel- und Serienreize (N. ventralis posteromedialis) und contralaterale corticale Einzel- und Serienreize (somatosensorisches Projektionsgebiet S I, S II) nachgewiesen werden. 2. Für die Gesamtheit der Neurone wurde mit zunehmender Latenzzeit der Entladung auf periphere Reize eine Zunahme der prozentualen Ansprechbarkeit und der Latenzzeit der Antwort auf zentrale Reize beobachtet. 3. Die Neurone, deren periphere, thalamische und corticale Antworten Reizfrequenzen von 50 Hz und mehr folgten, hatten im Mittel kürzere periphere Latenzzeiten als Neurone, die Reizfrequenzen von 50 Hz nicht folgten. 4. Bulbäre Neurone, die mit thalamischen Reizen antidrom erregt wurden (lemniscale Neurone), unterschieden sich im Mittel von den übrigen Neuronen durch kürzere Latenzzeiten für periphere und zentrale Reize. 5. Es wurden lemniscale Neurone beobachtet, die mit corticalen Reizen monosynaptisch erregt werden konnten. 6. Neurone mit kleinen peripheren rezeptiven Feldern hatten im Mittel kürzere Latenzzeiten auf periphere Reize als Neurone mit großen rezeptiven Feldern. 7. Die periphere Reizantwort von Neuronen konnte durch vorausgehende thalamische und corticale Reize gehemmt werden. Im Mittel wurde die Hemmung bei Neuronen mit Latenzzeiten auf periphere Reize häufiger beobachtet. 8. Mögliche Bahnen, die an der Übertragung thalamo-bulbärer Effekte beteiligt sind, wurden diskutiert und schematisch dargestellt. Die Ergebnisse wurden mit statistischen Methoden geprüft.
    Notes: Summary 1. Functional properties of excitatory connections from cortex, thalamus and periphery to a total of 438 trigeminal bulbar neurons of the cat have been investigated extracellularly. For the sample considered, correlations between latency of response to ipsilateral electrical single stimuli, contralateral electrical thalamic single and serial stimuli (N. ventralis posteromedialis) and also contralateral electrical cortical single and serial stimuli (somatosensory areas S I, S II) were established. 2. With increasing peripheral latency of response, the percentage of neurons responding to central stimulation increased as well. 3. Neurons following thalamic, cortical or peripheral stimulation frequencies of 50 cps or more showed in the average shorter latencies of response compared with neurons that could not be driven with 50 cps stimulation. 4. Bulbar neurons antidromically invaded by stimulation of the thalamus showed shorter latencies to peripheral, thalamic and cortical stimuli compared with other neurons. 5. Lemniscal neurons that could be activated monosynaptically by cortical stimulation have been observed. 6. Neurons with a small peripheral receptive field had in the average a shorter latency to peripheral stimuli than neurons with a large receptive field. 7. Responses to peripheral stimuli could be inhibited by preceding thalamic and cortical stimuli. 8. Possible pathways that are involved in transmission of thalamo-bulbar effects have been discussed and schematically represented. 9. All results have been examined by means of statistical methods.
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  • 75
    ISSN: 1432-2013
    Keywords: Hippocampus ; Corpus geniculatum laterale ; Katze ; Mikroelektrophorese ; Acetylcholin ; Hippocampus ; Lateral Geniculate Body ; Cat ; Microelectrophoresis ; Acetylcholine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary 1. Hippocampal and lateral geniculate neurones in anaesthetized cats (Chloralose-Urethane) were examined with multibarrelled microelectrodes, testing their responsiveness to microelectrophoretic application of acetylcholine and photic stimulation. 2. In the ventral hippocampus and in the lateral geniculate body 60% of all neurones responded to acetylcholine. 3. Hippocampal neurones were activated with relatively short delay, often less than 1 sec. By contrast, lateral geniculate neurones responded with a latency period of 2–12 sec. The recovery time after acetylcholine-microelectrophoresis was found to be 10–20 sec in both regions. 4. The response of hippocampal and lateral geniculate neurones to photic stimulation was enhanced by local application of acetylcholine; even during phenobarbital depression the photic responses were restored by acetylcholinemicroelectrophoresis.
    Notes: Zusammenfassung 1. Neurone im Gebiet des Hippocampus und des Corpus geniculatum laterale der mit Chloralose-Urethan narkotisierten Katze wurden mit mehrkanüligen Mikroelektroden auf ihre Ansprechbarkeit auf mikroelektrophoretisch appliziertes Acetylcholin und auf optische Reizung untersucht. 2. Im ventralen Hippocampus und im Corpus geniculatum laterale wurden 60% aller untersuchten Neurone durch Acetylcholin aktiviert. 3. Die Neurone des Hippocampus wurden nach relative kurzer Latenz, oft weniger als 1 sec, aktiviert. Neurone des Corpus geniculatum laterale dagegen zeigten eine Latenz von 2–12 sec. Die Zeit nach der Mikroelektrophorese bis zur Wiedererreichung der normalen Aktivität betrug 10–20 sec für beide Gebiete. 4. Die Acetylcholin-Mikroelektrophorese verstärkte die Reizantwort der Neurone des Hippocampus und des Corpus geniculatum laterale auf visuelle Reizung. Die nach Phenobarbital abgeschwächte Antwort auf visuelle Reizung wurde durch Acetylcholin-Mikroelektrophorese wieder verstärkt.
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  • 76
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    Experimental brain research 3 (1967), S. 117-134 
    ISSN: 1432-1106
    Keywords: Supraspinal effects ; Extrapyramidal pathways ; Spinal activity ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Effects of stimulation of the sensorimotor cortex on activity of the lumbosacral cord were studied in pyramidotomized cats. The following actions initiated by corticofugal volleys were found: 1. postsynaptic effects on motoneurones, mainly excitatory in flexor motoneurones and inhibitory or excitatory in extensor motoneurones, 2. facilitation of spinal reflexes to motoneurones at an interneuronal level, 3. depolarization of presynaptic terminals of group Ib and cutaneous fibres. The latencies of the earliest cortical effects on motoneurones as indicated by modification of monosynaptic reflexes or PSPs were 9–12 msec. Experiments with lesions of different spinal tracts suggest that the effects on motoneurones are mediated mainly by pathways in the ventral part of the lateral funiculus (probably reticulospinal), the facilitation of reflex transmission by pathways in the dorsal part of the lateral funiculus (probably rubrospinal) and primary afferent depolarization by both the former and the latter pathways. The strongest cortical effects were evoked by stimulation of an area around the postcruciate dimple.
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  • 77
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    Experimental brain research 3 (1967), S. 372-381 
    ISSN: 1432-1106
    Keywords: Red nucleus ; Inferior olive ; Muscle spindles ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In cats anesthetized with halothane the influence of central stimulation upon the dynamic sensitivity of muscle spindles in the flexor digitorum longus muscle was studied. One mesencephalic and one medullary region were found which caused an increase in dynamic spindle sensitivity when stimulated electrically. Histological identification of stimulating points showed these regions to be the caudal pole of the red nucleus and the inferior olivary nucleus respectively. Lesions in the olive decreased rubral effects on the spindles, indicating that the red nucleus and the olive are parts of the same system descending to dynamic fusimotor neurones. Further evidence for this point are given in a following paper (APPELBERG 1967).
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  • 78
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    Experimental brain research 3 (1967), S. 353-367 
    ISSN: 1432-1106
    Keywords: Tectum opticum ; Movement detecting neurons ; Directional sensitive neurons ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurden 80 Einheiten des Tectum opticum der Katze abgeleitet und ihre Reaktionen auf stationäre und bewegte optische Reize geprüft. Neben den Neuronen, die in ihrer Reaktionsweise retinalen Einheiten vergleichbar waren, fanden sich überwiegend (89%) Neurone, die auf bewegte optische Reize reagierten. Unter den letzteren zeigte die Mehrheit (70%) richtungsspezifisches Verhalten. Bei einigen Neuronen war in einem beschränkten Bereich von 1–7.5∘/sec die Reaktion gesetzmäßig abhängig von der Winkelgeschwindigkeit des Bewegungsreizes (Potenzfunktion mit dem Exponenten 0.67). Die rezeptiven Felder waren meist rund mit einem durchschnittlichen Durchmesser von 8.1∘ (3–22∘). 68% der Einheiten reagierten nicht auf diffusen Lichtreiz. Die Reaktionen auf nicht bewegte Punktlichtreize waren rasch adaptierend und inkonstant in ihrer Art und Stärke. In kurzen Abständen mehrfach wiederholte Bewegungsreize bewirkten bei einem Teil der Bewegungsneurone rasche Adaptation. Zwei kurz aufeinander folgende Punktlichtreize ergaben eine Reaktion, die niedriger als die Summe der Erregungen der jeweils einzeln gegebenen Lichtreize war, wenn die zeitliche Folge der beiden Reize der Vorzugsrichtung des Neurons entgegengesetzt war. Bei Reizfolgen entsprechend der Vorzugsrichtung entsprach die Gesamtreaktion der Summe der Einzelreizantworten. Dies läßt vermuten, daß die Richtungsspezifität durch unilaterale Hemmung bedingt ist.
    Notes: Summary Recordings were made from 80 single units in cat's Tectum opticum during visual stimulation with moving and stationary optic stimuli. The majority of units (89%) showed movement specific reactions, the rest behaved functionally similar to retinal or geniculate neurons. 70% of the movement specific units showed directional selective reactions. The receptive fields, as determined with stationary and moving stimuli were mostly circular with an average diameter of 8.1° (range 3–22°). Stimuli passing through the periphery of the field led to less pronounced reactions than those going through the center. In 10 out of 30 units, the relation between discharge rate and angular velocity in a restricted range from 1°–7.5°/sec could be approximated by a power function with an exponent of 0.67. Above 10°/sec irregular and unsystematic alterations of reactivity were observed. 68% of the tectal units recorded did not respond to diffuse light stimuli. The reactions to localized intermittent stationary light stimuli were mostly off (42%) or on-off-responses (19%) and were characterized by fast adaptation, change of reaction type during successive intermittent stimulation and by the absence of an antagonistic field-structure. Stimulation of adjacent points in a temporal sequence corresponding to movement opposite to the most sensitive direction of a directional specific neuron led to a reaction which was below the sum of the reaction of the two stimuli given alone. At a temporal sequence of the two stimuli such as to simulate the most sensitive direction, the resulting reaction corresponded to the sum of the reactions of both stimuli given alone. This suggests a mechanism of unilateral inhibition to be responsible for directional selectivity.
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  • 79
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    Experimental brain research 3 (1967), S. 382-390 
    ISSN: 1432-1106
    Keywords: Red nucleus ; Inferior olive ; Cerebellum ; Muscle spindles ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the preceding paper (Appelberg and Molander 1967) the caudal part of the red nucleus and parts of the inferior olivary nucleus were shown to cause increased dynamic sensitivity of muscle spindles when stimulated repetitively. The results to be presented will show that single shock electrical stimulation in the caudal part of the red nucleus evoked a field potential in the inferior olivary nucleus. This response seemed to be monosynaptically evoked and was observed only in parts of the olive where repetitive stimulation caused increased dynamic sensitivity of muscle spindles. Stimulation in the red nucleus as well as single shock stimulation in the actual part of the inferior olive also caused a potential in the vermis of the posterior cerebellar lobe. In conditioning — test experiments with the two stimuli the conditioning shock was seen to cause alternating periods of decreased and increased responsiveness in the pathway concerned. The same type of interaction was seen between two responses caused by double shock stimulation in the red nucleus. It is concluded that information from the caudal part of the red nucleus reaches dynamic fusimotor neurones in the spinal cord via a relay in the inferior olivary nucleus; an additional relay in the pathway is also predicted. The cerebellum seems to receive information about ongoing activity in the pathway but mesencephalic stimulation was seen to cause spindle effects also in decerebellated animals.
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  • 80
    ISSN: 1432-1106
    Keywords: Monosynaptic reflex ; Presynaptic inhibition ; Extensor nerve ; Spinal cord ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Electrical stimulation of extensor nerves of the ankle has been used to investigate the presynaptic inhibition in a synergic monosynaptic reflex arc. 2. Depression of monosynaptic reflex response as well as increase in excitability of Ia afferent terminals in the MG (medial gastrocnemius) reflex arc is found following the conditioning stimulation of LGS (lateral gastrocnemius-soleus) nerve at Group I strength. 3. Excitability increase of the Ia terminals of the LGS nerve is also found following the conditioning stimulation of either a group of fibres of the same nerve or the MG nerve. 4. Conditioning by Group I afferent volleys from either the LGS or the PBST (posterior biceps-semitendinosus) muscles produces comparable changes in excitability of the Ia terminals from MG muscle. 5. The hypothesis is advanced that the depression of the monosynaptic reflex discharge during repetitive stimulation is mainly caused by the depolarization of the Ia afferent terminals, i.e. by presynaptic inhibition.
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  • 81
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    Experimental brain research 3 (1967), S. 95-110 
    ISSN: 1432-1106
    Keywords: Mossy fibre pathways ; Cerebellum ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Field potentials in the vermal cerebellar cortex generated by a mossy fibre volley along reticulo-, cuneo- and spino-cerebellar tracts were recorded with microelectrodes and analysed by the same procedures as was done for the mossy fibre responses in the cortex by juxta-fastigial (J.F.) and trans-folial (T.F.) stimulations in the previous paper (Eccles, Sasaki and Strata 1967a). li 3. All these results corroborate the analyses and the interpretations of the field potentials in the cerebellar cortex produced by T.F.- and J.F.-evoked mossy fibre volleys in the previous paper. 4. There have not been found electrophysiologically significant differences, as Szentágothai (1964) has suggested, between the modes of mossy fibre terminations of the reticulo-cerebellar and the spino-cerebellar systems.
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  • 82
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    Diabetologia 3 (1967), S. 249-265 
    ISSN: 1432-0428
    Keywords: Spontaneous Diabetes ; Dog ; Cat ; Diabetes in dogs and cats ; Pancreas ; Islets of Langerhans ; B cells ; Insulitis ; Hyalin ; Capillaries ; Kidney ; Retina ; Microaneurysms ; Pituitary
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les auteurs présentent une étude histopathologique de 30 chiens et de 5 chats spontanément diabétiques. — Les îlots de Langerhans et les cellules B étaient fortement diminués en nombre chez la grande majorité des chiens. Les cellules B étaient souvent dégranulées et hydropiques. Chez les chiens dont le diabète avait évolué pendant longtemps, les îlots étaient très rares et les cellules B absentes. — Chez les 5 chats spontanément diabétiques par contre, les îlots et les cellules B étaient nombreuses. Les cellules B étaient dégranulées et hydropiques chez 4 chats. Chez 1 des chats, les cellules B paraissaient normales. De nombreux îlots présentaient des dépôts de substance hyaline dans le stroma. Chez un chat, il existait une infiltration lymphocytaire très dense dans un îlot. — Ni chez les chiens, ni chez les chats, il n'a été vu de lésions glomérulaires identiques à celles de glomérulosclérose diabétique humaine. Les lésions les plus fréquentes consistaient en un épaississement des axes membraneux des touffes glomérulaires et une hypertrophie de la paroi des artérioles afférentes.— Dans les rétines des chiens diabétiques il existait une acellularité focale ou généralisée de la paroi des capillaires. Un petit nombre de microanévrysmes ont été trouvés chez 3 chiens diabétiques. L'incidence plus faible des lésions de rétinopathie vasculaire, comparativement aux diabétiques humains, s'explique probablement par la durée de vie plus courte du chien et du chat. Il est possible aussi que les capillaires rétiniens de ces animaux soient moins susceptibles de développer des lésions dégénératives. — Un degré marqué de stéatose hépatique a été observé chez beaucoup de chiens et de chats. Les surrénales étaient souvent hypertrophiées et contenaient des adénomes, mais ces lésions ne paraissent pas différentes de celles que l'on peut trouver chez des chiens et des chats non diabétiques de même âge. L'hypophyse a été prélevée chez 7 chiens. Dans 2 cas, elle contenait un adénome. Une étude cytologique plus complète des hypophyses sera publiée ultérieurement.
    Abstract: Zusammenfassung Die Autoren berichten über die Ergebnisse von Untersuchungen an 30 spontan-diabetischen Hunden und 5 spontan-diabetischen Katzen. Bei der großen Mehrzahl der diabetischen Hunde war die Zahl der Langerhansschen Inseln und der B-Zellen stark herabgesetzt. Die B-Zellen waren oft degranuliert und hydropisch. Bei Hunden mit schon lang anhaltender Krankheit waren die Inseln nur noch vereinzelt und B-Zellen überhaupt nicht mehr nachweisbar. — Im Gegensatz zu diesen Ergebnissen fanden sich bei allen 5 Katzen zahlreiche Inseln und B-Zellen. Bei 4 dieser Katzen jedoch waren die B-Zellen, wie bei den Hunden, degranuliert und hydropisch entartet. Bei einer Katze war das Aussehen der B-Zellen normal. Im Stroma der Inseln von 2 Katzen konnten starke Hyalinablagerungen nachgewiesen werden. In einem Falle zeigten die Inseln eine starke lymphocytäre Infiltration. — Weder bei den Hunden noch bei den Katzen waren typische Läsionen der Glomeruli, wie sie bei der Glomerulosklerose des menschlichen Diabetes auftreten, nachweisbar. Die häufigsten Veränderungen bestanden aus einer mehr oder weniger ausgeprägten Verdickung des mesangialen Teils der Kapillaren der Glomeruli und aus einer Hypertrophie der Wand der zuführenden Arteriolen. Bei einigen Hunden und Katzen bestanden auf chronische Pyelonephritis zurückführende Narben. — In der Retina der diabetischen Hunde waren zellenlose und funktionslose Kapillaren vorhanden, und degenerierte Pericyten (“ghostcells”) waren häufiger als bei normalen Hunden. In drei Hunden wurden einige Mikroaneurismen beobachtet. Daß diese für die Retinopathie des Diabetes typischen Läsionen beim Hund verhältnismäßig selten auftreten könnte mit der kürzeren Lebensdauer der Krankheit bei diesen Tieren zusammenhängen. Es ist jedoch nicht ausgeschlossen, daß die Retina von Hunden und Katzen weniger zu degenerativen Veränderungen neigt. — In der Leber vieler Hunde und Katzen wurde eine schwere Steatose beobachtet. In vier Hunden zeigte sich beginnende Lebercirrhose. In diabetischen Hunden und Katzen waren die Nebennieren oft hypertrophisch und enthielten Adenome, die allerdings auch bei nichtdiabetischen alternden Hunden beobachtet wurden. In 2 von 7 Hypophysen diabetischer Hunde fanden sich Adenome, über deren cytologische Untersuchung in einer späteren Veröffentlichung berichtet wird.
    Notes: Summary A histological study of 30 spontaneously diabetic dogs and 5 spontaneously diabetic cats is presented. — The islets of Langerhans and the B cells were strongly reduced in number in a large majority of the diabetic dogs. The B cells were often degranulated and hydropic. In cases of longer duration, the islets were scarce and B cells could no longer be found. — In contrast to the findings in diabetic dogs, all five cats showed numerous islets and B cells. However in 4 cats, the B cells showed complete degranulation and hydropic changes, as in the dogs. In one cat, the B cells had a normal appearance. Extensive hyalin deposits were found in the stroma of the islets in 2 cats. In one cat, an islet showed a dense lymphocytic infiltration. — No lesions identical to human diabetic glomerulosclerosis were found in any of the dogs or cats. The changes most frequently observed were a variable degree of thickening of the mesangial stalk of the glomerular capillaries, and an hypertrophy of the wall of the afferent arteriole. Scars resulting from chronic pyelonephritis, were found in a few dogs and cats. — Acellular, non-functional capillaries, with degeneration of pericytes (“ghost-cells”) were found in larger numbers in the retinas of the diabetic dogs than in non-diabetic control dogs. A very few microaneurysms could be found in 3 dogs. The lower incidence of the most typical lesions of diabetic retinopathy in dogs, as compared with the human diabetic, is probably related to the shorter duration of the disease in these animals. However, a lower susceptibility of the retina of dogs and cats to develop degenerative changes cannot be excluded. — A severe steatosis was observed in the liver of many dogs and cats. In 4 dogs, the liver showed early cirrhosis. In diabetic dogs and cats, the adrenal cortex often showed hypertrophy and contained adenomas; however, these changes have also been reported in non-diabetic aging dogs. An adenoma was found in 2 of the 7 pituitaries obtained from diabetic dogs; the cytological aspect of these adenomas and of the pituitaries will be reported in a later publication.
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  • 83
    ISSN: 1432-1912
    Keywords: Dopa formation ; Tyrosine hydroxylase ; Dopa decarboxylase ; Adrenal gland ; Cat ; Dopa-Bildung ; Tyrosin-Hydroxylase ; Dopa-Decarboxylase ; Nebenniere ; Katze
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Nach Injektion von H-3-Tyrosin wurde die Bildung von H-3-Dopa in verschiedenen Organen (Nebenniere, Hirnstamm, Herz, Leber, Niere, Milz, Pankreas und Blut) des Huhnes und der Katze gemessen. Die Isolierung von H-3-Dopa wurde wie folgt durchgeführt: 1. Die säurelösliche Fraktion wurde durch Papierhochspannungselektrophorese im Pyridin-Eisessig-Puffer vorgetrennt. 2. Die Tyrosin-Dopa-Bande wurde eluiert und papierchromatographisch aufgetrennt. 3. Die Dopa-Bande wurde erneut eluiert und Dopa wurde als Borat-Komplex durch Papierhochspannungselektrophorese in einem Borat-Puffer charakterisiert. Nach Hemmung der Dopa-Decarboxylase mit NSD-1034 [N-Methyl-N-(3-hydroxybenzyl)hydrazin-dihydrogenphosphat] betrug der Anteil des H-3-Dopa an der Gesamtaktivität der säurelöslichen Fraktion der Nebenniere beim Huhn 4% und bei der Katze 5%. Unter diesen Bedingungen konnte H-3-Dopa in allen anderen untersuchten Organen nicht nachgewiesen werden. Ohne NSD-1034 fand sich auch in der Nebenniere kein H-3-Dopa. Bei Versuchen an Katzen wurde die H-3-Dopa-Konzentration im venösen Blut der Nebenniere gemessen. In einigen Blutproben betrug die H-3-Dopa-Aktivität bis zu 3% der Gesamtaktivität. Nahezu die gesamte von der Nebenniere gebildete Menge an H-3-Dopa wurde an das venöse Blut abgegeben. Nur 5% des neugebildeten Dopa waren am Ende des Versuches in der Nebenniere nachweisbar. Das zeigt, daß Dopa von der Nebenniere nicht gespeichert wird. Im Blut anderer Organe fand sich hingegen kein Dopa. Die Dopa-Konzentration der Nebenniere betrug nach Blockierung der Dopa-Decarboxylase ca. 1 μg/g Naßgewebe und war ohne Hemmung 〈0,2 μg/g. Die Dopa-Neubildungsrate der Nebenniere wurde abgeschätzt aus dem H-3-Dopa-Gehalt der Nebenniere sowie aus dem zeitlichen Verlauf der H-3-Dopa-Aktivität und der spezifischen Aktivität des freien H-3-Tyrosins. Bei der Katze werden von einer einzelnen Nebenniere etwa $$\frac{{0,02{{\mu}}g}}{{\min /kg}}$$ Dopa gebildet $$\left( { = \frac{{1,2{{m\mu Mol}}}}{{\min /1{{gNebenniere}}}}} \right)$$ .
    Notes: Summary After injection of H-3-tyrosine the synthesis of H-3-dopa was measured in various organs (adrenal glands, brain stem, heart, liver, kidney, spleen, pancreas and blood) of fowl and cat. The isolation of H-3-dopa was carried out in the following way: 1. The acid soluble fraction was fractionated by high voltage paper electrophoresis in a pyridine-acetic acid-buffer. 2. The tyrosine-dopa-spot was eluated and descending paper chromatography was carried out. This system separated tyrosine from dopa. 3. The dopa-spot was eluated again, and dopa was characterized by its complex with boric acid in paper high voltage electrophoresis in a boric acid-sodium hydroxide-buffer. After inhibition of the dopa decarboxylase by NSD-1034 [N-methyl-N-(3-hydroxybenzyl)hydrazine dihydrogen phosphate] H-3-dopa represented in adrenal glands of domestic fowl 4% and in those of cats 5% of the total radioactivity. Under these conditions in all the other organs investigated H-3-dopa could not be detected. Without NSD-1034 H-3-dopa was undetectable in the adrenals, too. In experiments with cats the H-3-dopa concentration in the venous blood of the adrenals was measured. In some samples H-3-dopa represented up to 3% of the total radioactivity. Nearly the total amount of H-3-dopa formed in the adrenals was secreted into the venous blood, and only 5% of the total amount were detected in the gland at the end of the experiments. This demonstrates that dopa cannot be stored by the adrenals. We failed to detect H-3-dopa in blood from any other organ. The concentration of dopa in the adrenals was about 1 μg/g wet weight after inhibition of dopa decarboxylase and without inhibition it was 〈0.2 μg/g wet weight. The dopa synthesis rate in adrenals was calculated from the H-3-dopa activity in the gland and in the venous blood and from the specific activity of its precursor H-3-tyrosine. One adrenal of the cat synthetized 0.02 μg dopa/min·kg body weight (=1.2 mμMol/min·1 g adrenal).
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  • 84
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    Experimental brain research 1 (1966), S. 1-16 
    ISSN: 1432-1106
    Keywords: Inhibitory interneurones ; Cerebellum ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Extracellular microelectrode recording has been employed to study the responses of three types of interneurones in the cat cerebellar cortex: basket cells, superficial stellate cells and Golgi cells. The large unitary spike potentials of single cells were sharply localized and presumably were generated by impulse discharges from the cell somata. The characteristics of their responses described below sharply distinguished them from Purkinje cells. 2. The parallel fibre volleys generated by surface stimulation of a folium evoked brief repetitive discharges that were graded in respect of frequency and number. Maximum responses had as many as 10 impulses at an initial frequency of 500/sec. 3. At brief test intervals there was facilitation of the response to a second parallel fibre volley; at about 50 msec it passed over to depression for over 500 msec. 4. Stimulation deep in the cerebellum in the region of the fastigial nucleus (juxta-fastigial, J.F.) evoked by synaptic action a single or double discharge, presumably by the mossy fibre-granule cell-parallel fibre path, but climbing fibre stimulation from the inferior olive also usually had a weak excitatory action evoking never more than one impulse. 5. J.F. stimulation also had an inhibitory action on the repetitive discharge evoked by a parallel fibre volley. Possibly this is due to the inhibitory action of impulses in Purkinje cell axon collaterals. 6. There was a slow (7–30/sec) and rather irregular background discharge from all interneurones. The inhibitory actions of parallel fibre and J.F. stimulation silenced this discharge for some hundreds of milliseconds, probably by Golgi cell inhibition of a background mossy fibre input into granule cells. 7. All these various features were displayed by cells at depths from 180 to 500 μ; hence it was concluded that superficial stellate, basket and Golgi cells have similar properties, discrimination being possible only by depth, the respective depth ranges being superficial to 250μ, 250μ to 400μ, and deeper than 400μ.
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    Experimental brain research 1 (1966), S. 17-39 
    ISSN: 1432-1106
    Keywords: Parallel fibres ; Purkinje cells ; Cerebellum ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. When electrical stimuli were applied to the surface of a cerebellar folium by a local electrode (LOC), there was a propagated potential wave along the folium with a triphasic (positive-negative-positive) configuration. 2. Investigations by microelectrode recording established that this wave is produced by impulses propagating for at least 3 mm and at about 0.3 m/sec along a narrow superficial band or “beam” of parallel fibres. As expected from this interpretation, there was an absolutely refractory period of less than 1 msec and impulse annihilation by collision. 3. Complications occurred from the potential wave forms resulting from the excitation of mossy fibres by spreading of the applied LOC stimulus. These complications have been eliminated by chronically deafferenting the cerebellum. 4. When recording within the beam of excited parallel fibres there was a slow negative wave of about 20 msec duration, and deep and lateral thereto, there was a slow positive wave of approximately the same time course. 5. These potential fields were expressed in serial profile plots and in potential contour diagrams and shown to be explicable by the excitatory and inhibitory synaptic action on Purkinje cells: excitatory depolarizing synapses of parallel fibre impulses on the dendrites; and hyperpolarizing inhibitory synapses of stellate and basket cells respectively on the dendrites and somata. The active excitatory synapses would be strictly on the parallel fibre beam and the inhibitory concentrated deep and lateral thereto, which is in conformity with the axonal distributions of those basket and stellate cells that would be excited by the parallel fibre beam. 6. Complex problems were involved in interpretation of slow potentials produced by a second LOC stimulus at brief stimulus intervals and up to 50 msec: there was a potentiation of the slow negative wave, and often depression of the positive wave deep and lateral to the excited beam of parallel fibres. 7. Often the LOC stimulus evoked impulse discharge from the Purkinje cells, these discharges being inhibited by a preceding LOC stimulus.
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  • 86
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 1 (1966), S. 48-64 
    ISSN: 1432-1106
    Keywords: Spontaneous post-synaptic potentials (EPSPs, IPSPs) ; Motor cortex ; Cat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. Im motorischen Cortex von ausgewachsenen Katzen (mittlere Nembutalnarkose) wurden spontane postsynaptische Potentiale (PSP) mit intrazellulären Mikroelektroden untersucht. Die spontanen EPSP wurden mit ausgelösten EPSP nach schwachen Reizen in spezifischen (VL) und unspezifischen (CM) Thalamuskernen verglichen. 2. Spontane EPSP treten entweder einzeln oder gruppiert auf. spontane IPSP sind seltener und machen nur 3–10% aller spontanen PSP aus. Die kleinsten EPSP haben eine Amplitude von 150–200 μV, daneben kommen kleinere, flache Schwankungen des Membranpotentials vor. Die mittlere Amplitude von spontanen EPSP liegt bei 0.7 mV. Amplitudenhistogramme spontaner EPSP unterscheiden sich nicht wesentlich von solchen, die durch schwache CM- oder VL-Reize ausgelöst sind. 3. Die Anstiegssteilheit von spontanen EPSP liegt zwischen 2 und 15 msec. Es besteht keine konstante Beziehung zwischen Amplitude und Anstiegssteilheit. Der Potentialabfall ist annähernd exponentiell, die Zeitkonstante liegt zwischen 8 und 12 msec und ist damit etwas länger als die passive Neuronzeitkonstante (8.5±2.2 msec nach Creutzfeldt u. Mitarb., 1964b). Es bestehen keine konstanten Unterschiede der Zeitverläufe von spontanen, durch VL- oder CM-Reiz ausgelösten EPSP-Einheiten. 4. Die Intervallhistogramme von spontanen EPSP sind verschieden je nach dem, ob alle Intervalle oder nur Perioden mit sporadischer, nicht-gruppierter Aktivität ausgezählt werden. Nicht gruppierte EPSP haben längere mittlere Intervalle (70–80 msec). 5. Nach überschwelligen Thalamusreizserien ist sowohl die spontane als auch die reizinduzierte PSP-aktivität vermindert. Es kann jedoch nicht entschieden werden, inwieweit corticale und inwieweit thalamische Mechanismen für diese post-tetanische Depression verantwortlich sind. 6. Während reversibler Deafferentierung des Cortex durch K+-depolarisation afferenter Fasern und im chronisch isolierten Cortex finden sich keine spontanen PSP mehr, obwohl EPSP und IPSP am isolierten Cortex durch epicorticale Reize noch ausgelöst werden können. 7. Aus den Befunden wird geschlossen, daß die beobachteten PSP durch afferente und collaterale Faseraktivität ausgelöst sind. Für echte „Miniaturpotentiale” entsprechend Beobachtungen an Muskelendplatten findet sich kein Anhalt. Insofern repräsentiert das „synaptische Rauschen” corticaler Zellen die konvergierende Afferenz dieser Zellen und kann nicht als echtes „spontanes Rauschen” angesehen werden.
    Notes: Summary Spontaneous post-synaptic potentials (PSP's) of neurones of the motor cortex are analysed (intracellular recording, Nembutal anesthesia, cats). Distinct EPSP's either appear grouped or more sporadically distributed. Spontaneous EPSP's only represent about 3–10% of all spontaneous PSP's. The mean amplitude of EPSP's is about 0.7 mV. The smallest EPSP's have an amplitude of 150–200 μV, smaller slow fluctuations of the membrane potential (MP) are seen occasionally. Amplitude histograms of spontaneous EPSP's are similar to those of evoked EPSP units following weak thalamic stimulation. — The rising time of spontaneous EPSP's varies between 2 and 15 msec. and is not correlated with the peak amplitude. The decay is almost exponential, the time constant is between 8 and 12msec., thus being slightly higher than the neurone time constant of cortical pyramidal cells (8.5±2.2 msec. Creutzfeldt et al., 1964b). No consistant differences in time course and amplitude of “EPSP units” after VL and CM thalamic stimulation and of spontaneous EPSP's was found. Cortical and thalamic components of post-tetanic depression of spontaneous and evoked PSP activity cannot be distinguished. Interval histograms are different whether all EPSP's during sporadic and grouped activity or whether only sporadically appearing EPSP's are counted. Non-grouped EPSP's show longer mean intervals (between 70 and 80 msec.). — During reversible deafferentation with K+-depolarization of afferent fibers and in the chronically isolated cortex no spontaneous EPSP's or IPSP's are found eventhough membrane fluctuations of cells in the latter preparation may sometimes be difficult to distinguish from real EPSP's. In the chronically isolated cortex, EPSP's and IPSP's can still be elicited by epicortical stimulation. — From these findings it is concluded that the observed spontaneous PSP's represent “unit” EPSP's and IPSP's due to afferent and collateral fiber activity and that no true miniature potentials due to spontaneous liberation of transmitter substance can be recorded. Thus, the “synaptic noise” of cortical neurones represents convergent activity on these cells and consequently cannot be considered as true “spontaneous noise”.
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  • 87
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 2 (1966), S. 247-260 
    ISSN: 1432-1106
    Keywords: Synaptic excitation ; Hippocampus ; Pyramidal cells ; Dendritic activation ; Cat ; Rabbit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Following selective activation of four afferent paths that terminate exclusively on dendrites, only a small proportion of pyramidal cells in the hippocampal fields CA1 and CA3 discharged impulses. Following a single afferent volley, an EPSP was never observed even in cells synaptically excited. On tetanic stimulation (about 10/sec), a large EPSP developed, but this was not a prerequisite for an action potential. Studies of the extracellular field potentials corresponding to the EPSP and the population spike potential, indicated that the EPSP was generated across the dendritic membrane and that the spike was initiated in the neighbouring part of the dendritic tree, propagating from there along the thicker dendrites towards the soma. This conduction had an average velocity of 0.4m/sec, and, presumably, a relatively low safety factor. In certain cases, the intrasomatic electrode recorded small all-or-nothing spikes which presumably were generated in the dendritic tree. These small spikes (D-spikes) invaded the soma only if assisted by some additional depolarization, for example by frequency potentiation of excitatory synapses. The results indicate two functional types of pyramidal dendrites, the conducting and the synaptic type.
    Type of Medium: Electronic Resource
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