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Digitale Medien

Crystallization of a mammalian ornithine decarboxylase (1996)

Kern, Andrew ; Oliveira, Marcos A. ; Chang, Ning-Leh ; [weitere]

New York, NY : Wiley-Blackwell

Proteins: Structure, Function, and Genetics 24 (1996), S. 266-268

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Details

ISSN: 0887-3585

Schlagwort(e): polyamines ; group IV decarboxylases ; pyridoxal phosphate ; Chemistry ; Biochemistry and Biotechnology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Medizin

Notizen: Crystals of truncated (Δ425-461) pyridoxal-5′-phosphate (PLP)-dependent mouse ornithine decarboxylase (mOrnDC′) have been obtained that diffract to 2.2 Å resolution (P21212, a = 119.5 Å, b = 74.3 Å, c = 46.1 Å). OrnDC produces putrescine, which is the precursor for the synthesis of polyamines in eukaryotes. Regulation of activity and understanding of the mechanism of action of this enzyme may aid in the development of compounds against cancer. mOrnDC is a member of group IV PLP-dependent decarboxylases, for which there are no known representative structures.

Zusätzliches Material: 1 Tab.

Materialart: Digitale Medien

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