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Digitale Medien

Theoretical studies of hemoproteins. I. Mathematical description of the allosteric effect (1979)

Kikuchi, Takeshi ; Nishimoto, Kichisuke

New York, NY : Wiley-Blackwell

International Journal of Quantum Chemistry 15 (1979), S. 379-387

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Details

ISSN: 0020-7608

Schlagwort(e): Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: A new theoretical approach to the cooperativity of an enzyme has been proposed. When we applied the present theory to the allosteric effect of hemoglobin, we obtained a so-called Koshland-Nemethy-Filmer formula. Our theory suggested that the sigmoid curve becomes sharper when the affinity of the first oxygen molecule of the hemoglobin is smaller.

Zusätzliches Material: 4 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/qua.560150404

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