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Digitale Medien

Evidence for an hereditary defect in taurine transport in the ciliary epithelium of an inbred strain of rabbits (1983)

Harris, T. M. ; Nance, C. S. ; Sheppard, L. B. ; [weitere]

Springer

Journal of inherited metabolic disease 6 (1983), S. 163-166

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Details

ISSN: 1573-2665

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract The concentration of taurine in the aqueous humour and serum of 21 rabbits with hereditary buphthalmia (Bu rabbits-genotypebu/bu) was compared with the aqueous and serum taurine levels of eight strain-related normal rabits (JAX) and nine non-strain-related normal rabbits (MCV). There was a significant difference in the mean aqueous taurine concentration in each of the three groups. The Bu rabbits had only 29% of the MCV rabbits' level while the JAX rabbits were intermediate with 56% of the MCV level. It is suggested that some of the JAX rabbits may be heterozygous and the Bu rabbits homozygous for a semi-dominant allele of a gene that is less efficient in taurine transport in the ciliary epithelium than the normal allele represented by the MCV animals.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF02310874

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