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Digitale Medien

Influence of L-serine-O-phosphate on synaptic transmission in afferent synapses of the ampullae of Lorenzini of skates (1991)

Akoev, G. N. ; Andrianov, Yu. N. ; Ryzhova, I. V. ; [weitere]

Springer

Neurophysiology 23 (1991), S. 279-282

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ISSN: 1573-9007

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract The method of superfusion of the basal membranes of the ampullae of Lorenzini of skates was used to investigate the influence of L-serine-O-phosphate (SOP) on the background and evoked activity of afferent nerve fibers, as well as on the effects of application of agonists: exciting amino acids — L-glutamate (L-GLU), kainate (KA), quisqualte (Q), and N-methyl-D-aspartate (NMDA). It was found that SOP (threshold concentration 10−7 M) had an inhibiting effect on the background and evoked activity of the nerve fibers; depending on the concentration it decreased the stimulatory effects of L-GLU and NMDA and did not change the responses due to application of KA and Q. The data obtained suggest that the effects of SOP observed in the ampullae of Lorenzini are associated with its interaction with NMDA-type amino acid receptors.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01052557

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