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Digitale Medien

Application of Moment Analysis to Nonlinear Drug Disposition Described by the Michaelis–Menten Equation (1987)

Chow, Andrew T. ; Jusko, William J.

Springer

Pharmaceutical research 4 (1987), S. 59-61

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ISSN: 1573-904X

Schlagwort(e): mean residence time ; pharmacokinetics ; Michaelis–Menten elimination ; one-compartment model

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie

Notizen: Abstract An equation for the mean residence time (MRT) of drug in the body is derived for the system where drug is injected intravenously into a one-compartment model and eliminated by a single, capacity-limited process. This MRT is a complex function of dose, volume, V m, and K m but degenerates into the classical volume/clearance expression under limiting low-dose conditions (K m ≫ C 0). The equation was validated by comparison of the MRT obtained by direct calculation versus numerical area estimation for simulated data. The equation may be useful analytically in the estimation of the fundamental Michaelis–Menten parameters, V m and K m, from experimental data.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1023/A:1016486012446

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