ISSN:
1432-1912
Schlagwort(e):
Diethyl Ether Anaesthesia
;
Pentobarbitone Anaesthesia
;
Monoamine Synthesis in Rat Brain
;
Dopa
;
5-Hydroxytryptophan
;
NSD 1015 (3-hydroxybenzylhydrazine HCl)
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary Rats were injected i.p. with pentobarbitone sodium 40 mg/kg or were exposed to diethyl ether anaesthesia for 15 to 60 min. Monoamine synthesis in vivo was measured in various brain regions by determining the accumulation of dopa and 5-hydroxytryptophan (5-HTP) during 15 or 30 min after the i.p. injection of NSD 1015 (3-hydroxybenzylhydrazine HCl, 100 mg/kg), an inhibitor of the aromatic amino acid decarboxylase. Pentobarbitone retarded the formation of dopa and 5-HTP by about 25% in most brain regions but had no effect on striatal dopa formation. Ether accelerated the formation of dopa and 5-HTP in most brain regions, the action on striatal dopa being most pronounced (to 250% of control). The effect was generally somewhat less marked during the second than during the first half-hour of anaesthesia. A postanaesthetic inhibition of dopa formation was found in the striatum and of 5-HTP formation in whole brain. If hypothermia was allowed to develop, the stimulating action of ether on dopa and 5-HTP formation tended to be partly antagonized. A complex interaction between NSD 1015 and the hypothermic response to ether was observed.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00500346
