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Digitale Medien

Repeated electroconvulsive shock does not change [3H]-paroxetine binding to the 5-HT uptake site in rat cortical membranes (1988)

Gleiter, Christoph H. ; Nutt, David J.

Springer

Psychopharmacology 95 (1988), S. 68-70

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ISSN: 1432-2072

Schlagwort(e): Electroconvulsive shock ; 5-HT transporter complex ; β-Adrenoceptor ; [3H]-Paroxetine ; [3H]-Imipramine ; [3H]-Dihydroalprenolol ; Cerebral cortex ; Rat

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract The effects of repeated electroconvulsive shock on the 5-HT uptake site were studied in rat cortex using [3H]-paroxetine binding. This ligand was used because it is thought to directly label the 5-HT uptake site, whereas [3H]-imipramine may bind to a presynaptic recognition site different from the uptake site. No changes were found in the maximum number of [3H]-paroxetine binding sites and equilibrium dissociation constant after repeated electroconvulsive shock, whereas a parallel investigation of β-adrenoceptor binding showed the expected decrease in receptor number.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00212769

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