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Digitale Medien

Acetylation of procaine amide in man. A preliminary communication (1975)

Karlsson, E. ; Åberg, G. ; Collste, P. ; [weitere]

Springer

European journal of clinical pharmacology 8 (1975), S. 79-81

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Details

ISSN: 1432-1041

Schlagwort(e): Procaine amide ; N-acetylprocaine amide ; plasma concentration ; renal excretion ; acetylator phenotype

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary The metabolism of procaine amide was studied in 41 cardiac patients who had achieved steady state plasma concentrations of the drug. Acetylated procaine amide accounted for 31±12% (range 16 – 63%) of the overall urinary recovery of the drug and is therefore a main metabolite in man. Plasma levels of the metabolite were usually lower but sometimes exceeded those of the parent compound with variations between 1 and 15 µg/ml. The metabolite had a weaker effect than procaine amide on the maximal electrical driving velocity of isolated atrial strips from guinea pig.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00616419

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