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Digitale Medien

Evidence for the in vivo coating of a polyoma virus-induced tumor with antibodies specifically bound to their target-antigen (1978)

Robert, Françoise ; Dumont, F. ; Oth, D.

Springer

Cancer immunology immunotherapy 4 (1978), S. 171-177

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ISSN: 1432-0851

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary We made a comparative study of the in vivo binding of immunoglobulins (Ig) to a polyoma virus-induced ascitic tumor propagated in syngeneic or allogeneic mice. The Ig coat was found to appear more rapidly and to be denser in H 2-incompatible than in H 2-compatible mice. This suggests that antibodies were fixed specifically on strong normal transplantation antigens (H-2) recognized as non-self by allogeneic mice. Experiments with mice in which immunosuppression had been achieved by means of X-irradiation confirmed that the Ig fixed on SEWA cells are actively bound antibodies. The only mice that could fix Ig on tumor cells were those that had been specifically immunized against cell surface antigens shared by SEWA cells before irradiation, while mice hyperimmunized against nonrelated antigens could not.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00204736

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