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Digitale Medien

A neocentromere on human chromosome 3 without detectable α-satellite DNA forms morphologically normal kinetochores (1998)

Wandall, Annelise ; Tranebjærg, Lisbeth ; Tommerup, Niels

Springer

Chromosoma 107 (1998), S. 359-365

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Details

ISSN: 1432-0886

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Abstract. A neocentromere at 3q26 was observed in a father and his daughter on a chromosome 3 with deleted centromeric region. No α-satellite DNA was detectable at the 3q26 neocentromere, but it was weakly positive with anticentromere (CREST) antibodies. Electron microscopy showed that the neocentromere formed microtubule-associated kinetochores with normal morphology and of the same size as the kinetochores of other large chromosomes. The deleted centromere formed a small linear marker chromosome that reacted strongly with anticentromere antibodies, but showed reduced kinetochore size. The 3q26 neokinetochore was stable under adverse growth conditions, which often caused kinetochore loss in the original 3-centromere on the small marker.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s004120050319

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