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Digitale Medien

Antinociceptive effects of the stereoisomers of nicotine given intrathecally in spinal rats (1990)

Christensen, M. -K. ; Smith, D. F.

Springer

Journal of neural transmission 80 (1990), S. 189-194

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Details

ISSN: 1435-1463

Schlagwort(e): Nicotine enantiomers ; pain ; spinal analgesia ; rat

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Spinalized rats received an intrathecal injection of either (−)-nicotine or (+)-nicotine in order to study the stereoselectivity of antinociception. Pain threshold was measured using the tail-flick test. Both stereoisomers had antinociceptive effects, but (−)-nicotine was up to 970 times more potent, depending on test conditions. The antinociceptive action of (−)-nicotine was antagonized by mecamylamine and yohimbine but not by naloxone and atropine. The findings show that spinal mechanisms are highly stereoselective toward nicotine, and suggest that primarily nicotinergic andalpha-adrenergic receptors are involved in its central antinociceptive effects.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01245120

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