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Digitale Medien

Epidermal Growth Factor in Synaptosomal Fractions of Mouse Cerebral Cortex (1986)

Lakshmanan, J. ; Weichsel, M. E. ; Fisher, D. A.

Oxford, UK : Blackwell Publishing Ltd

Journal of neurochemistry 46 (1986), S. 0

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Details

ISSN: 1471-4159

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: Abstract: Using a specific and sensitive epidermal growth factor radioimmunoassay (EGF-RIA) we measured EGF concentrations in whole brain, cerebral cortex, and cerebral cortical synaptosomal (pinched-off presynaptic nerve terminals) fractions of 26-day-old mouse brain. The relative EGF concentration in synaptosomal fractions was significantly greater than the growth factor concentrations in whole brain or cerebral cortex. Intracerebral injection, in an amount of EGF, several-fold greater than whole brain EGF content, did not appreciably increase synaptosomal EGF concentration, suggesting that no artifact was involved. The high synaptosomal EGF content suggests a neurotransmitter or a neuromodulator role for EGF in the CNS.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1471-4159.1986.tb00621.x

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