ISSN:
0951-4198
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Physics
Notes:
The aim of this work was to probe the stereochemistry of a series of monosaccharides. Firstly, the underivatized sugars were investigated using linked-scans and tandem mass spectrometry on a ‘hybrid’ instrument (hybrid MS/MS) and secondly, a comparison of linked-scan and hybrid MS/MS was carried out on the butyl and phenyl boronate di-esters. In situ derivatization of the sugar to the boronate di-ester allows a negative-ion fast-atom bombardment (FAB) investigation with greater sensitivity than for the underivatized sugar. The linked-scan data allow a great deal of information on the structure and chemistry of the sugars to be obtained, but the sensitivity at lower mass is limited. The hybrid MS/MS data give similar fragmentation information, plus improved sensitivity at lower molecular weight.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/rcm.1290071209
