ISSN:
1040-0397
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The response characteristics of a new sensor for determining acetylcholine are reported. The sensor is based on a carbon paste electrode containing the enzymes acetylcholinesterase and choline oxidase and the electron transfer mediator tetrathiafulvalene (TTF). TTF is shown to efficiently reoxidize the reduced flavin adenine dinucleotide centers of choline oxidase. Acetylcholine calibration graphs are obtained in the range 10-6 to 10-3 M in pH 7.0 phosphate buffer, and the sensors are shown to operate efficiently at low applied potentials, where electrochemical interference due to oxidation of ascorbic acid is minimized.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/elan.1140030805
