ISSN:
1040-0397
Keywords:
Oxidation
;
Prolintane
;
Glassy carbon electrode
;
Voltammetry
;
Pharmaceutical formulations
;
Urine
;
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The oxidative behavior of 1-[1-(phenylmethyl)butyl]pyrrolidine, prolintane, was studied at a glassy carbon electrode using linear-sweep and differential-pulse voltammetry. The oxidation process was shown to be irreversible using 0.04 M Britton-Robinson buffer and was diffusion-adsorption controlled. Two voltammetric methods were developed for the determination of prolintane using different techniques: linear-sweep and differential-pulse voltammetry. The peak current varied linearly with prolintane concentrations in the range of 1.0 × 10-5 -2.5 × 10-4 M, with a detection limit of 8.5 × 10-6 and 4.0 × 10-6 M, and with relative standard deviations of 2.1 % and 3.1 %, respectively. The methods were applied to commercial preparations, giving relative errors less than 3.1 % and relative standard deviations lower than 4.8 % (n = 10).Determination of prolintane (down to the 8.5 × 10-8 M level) can be performed by using a preconcentration step prior to the determination by differential-pulse voltammetry in 0.04 M Britton-Robinson buffer (pH 8.0) with preconcentration potential of 0.0 V. The detection limit was found to be 6.2 × 10-8 M (4 min preconcentration) and the relative standard deviation for 2.5 × 10-7 M prolintane (n = 5) was 4.6 %. Applicability to human urine analysis is illustrated (recovery 98 ± 2 %). Standard additions method can be used to determine prolintane in real samples of urine.
Additional Material:
7 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/elan.1140090512
