ISSN:
1052-9306
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
In addition to the previously described metabolites, octanoyl glucuronide was identified in the urine of four children who received medium-chain triglycerides. Octanoyl glucuronide in the urine of a child after ingestion of medium-chain triglycerides (C8:C10, 3:1) was quantitated as octanoic acid after glucuronidase treatment by means of gas chromatography/mass spectrometry. The urinary excretion increased rapidly to a maximum 1-2 h after ingestion, and decreased therafter. During 0-3 h, 6.11 μmol of octanoyl glucuronide was excreted, which comprised 0.034% octanoic acid administered as glyceride, and 0.07% octanoic acid was postulated to be excreted as glucuronide within 24 h. Neither decanoyl glucuronide nor hexanoyl glucuronide was detected. Glucuronidation of branched medium-chain fatty acids, whose β-oxidation is hindered, has been described previously. The present findings show that even straight-chain fatty acids undergo glucuronidation, although to a lesser extent, in addition to ω-oxidation and β-oxidation.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bms.1200131103
