ISSN:
0030-493X
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
In comparing N-acetylmorpholine to closely related systems, two major differences in fragmentation are observed. M-15 and M-43 fragments, although quite common to such systems, are unusual with respect to their genesis. Formation of the M-15 fragment by loss of C-3 instead of the anticipitated loss of C-2 or C-8 is evident from shifts in the spectra of deuterated analogs. The M-43 species arises from total loss of the N-acyl substituent rather than the usual two-step loss of ketene plus a ring hydrogen. These data are presented in support of mechanistic rationale involving radical induced ring contraction to a common intermediate molecular ion. Techniques of high resolution mass spectrometry and isotope labeling have been employed to substantiate certain mechanistic details.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/oms.1210010113