ISSN:
0030-493X
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The mass spectra of 2,2′-anhydrouridines substituted in the 3′ and 5′ positions were studied. When the substituents were acetyl, pivaloyl, trifluoroacetyl or trimethylsilyl, it was found that specific fragmentations occured which could identify the position of the substituent. The specific fragmentations often resolve earlier ambiguities in the interpretation of mass spectra of 2,2′-anhydropyrimidine derivatives. Mono-acetyl and mono-pivaloyl 2,2′-anhydrouridines are not easily distinguished because of thermal reactions in the sample probe. They may be readily distinguished, however, by acetylation (with acetic anhydride-d6 for the mono-acetyl isomers), trifluoroacetylation or trimethylsilylation, followed by mass spectral analysis of the reaction product.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/oms.1210070310
