ISSN:
0749-1581
Keywords:
Conformation
;
3′,5′-O-(Di-tert-butylsilanediyl) nucleosides DESERT 1H NMR
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The solution conformations of nine 3′,5′-O-(di-tert-butylsilanediyl) nucleosides, new sila analogues of cyclic nucleotides, were studied by proton NMR spectroscopy. The furanose rings of all the compounds studied are forced to take on the C-3′-endo conformation by the 3′,5′-cyclization. The conformations at the glycosidic bond of the adenosine and deoxyadenosine derivatives were determined as mixtures of syn and anti conformations by the DESERT method; the fractions of anti conformation for these derivatives were 0.58 and 0.41, respectively.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260311202
