ISSN:
0887-6134
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Electron impact mass spectra of the oral coumarin anticoagulant phenprocoumon and its 4-O-alkyl and 2-O-alkyl (methyl and ethyl) derivatives (including deuterium and 13C-labelled compounds) have been analysed using accurate mass measurements and B/E and B2/E constant linked-scan techniques; fragmentation routes have been proposed which are different from those for simple coumarins and other oral coumarin anticoagulants. All compounds showed an ethyl group migration from the phenylpropyl side chain to the coumarin ring; the O-alkyl derivatives presented additionally a rearrangement with bond formation between a C atom of the O-alkyl group and the phenyl ring of the side chain. Previous literature reports about fragment ion structures for methylated phenprocoumon have been revised.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bms.1200180404
