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Digitale Medien

Dual inhibitory effect of bredinin (1989)

Kusumi, T. ; Tsuda, M. ; Katusunuma, T. ; [weitere]

New York, NY [u.a.] : Wiley-Blackwell

Cell Biochemistry and Function 7 (1989), S. 201-204

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Details

ISSN: 0263-6484

Schlagwort(e): Bredinin ; GMP synthetase ; IMP dehydrogenase ; inhibition of GMP synthesis ; Chemistry ; Biochemistry and Biotechnology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Medizin

Notizen: Bredinin inhibition of cell growth was investigated in the mouse lymphoma cell line L5178Y. Bredinin caused the accumulation of IMP and the reduction of XMP. It was converted to the 5′-phosphate within the cells. Bredinin 5′-phosphate but not bredinin competitively inhibited both IMP dehydrogenase and GMP synthetase. Thus the inhibition of cell growth is probably due to bredinin 5′-phosphate, which inhibits the consecutive enzyme reactions IMP dehydrogenase and GMP synthetase. These inhibitions result in the accumulation of IMP and the reduction of XMP.

Zusätzliches Material: 2 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/cbf.290070308

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