ISSN:
0952-3499
Keywords:
enkaphalin
;
dynorphin
;
naltrexamine
;
somatostatin
;
substance P
;
opioid receptors
;
Chemistry
;
Biochemistry and Biotechnology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
Notes:
Conformations of regulatory peptides interacting lipid membranes were compared with those of chemically constrained molecules that react-selectively with different receptor classes. Striking similarities in the topochemistry of molecules with similar activity were observed, The membrane-induced topomers were almost congruent with the topomers that are selectively recognized by the same receptors. Finally, the ideas developed in the membrane compartments theory allow a quantitative prediction of receptor preference are compatible with our present knowledge of receptor structure.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jmr.300080103