ISSN:
0952-3499
Keywords:
Porphyrin
;
Kemp's triacid
;
H-bonding
;
substrate binding
;
imidazole
;
purine
;
1,2,3-triazole, 1,2,4-triazole
;
Chemistry
;
Biochemistry and Biotechnology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
Notes:
Porphyrin-based molecular clefts equipped with a strategically positioned carboxylic group have been synthesized. These ditopic porphyrins exhibit excellent binding affinity for many neutral substrates. X-ray structures of a porphyrin-water inclusion complex and a Zn(porphyrin)-methanol complex reveal how the carboxylic group interacts with substrates via H-bonding. Multipoint recognition is demonstrated in the differential binding of 1,2,3- versus 1,2,4-triazole, suggesting the possible use of such receptors to separate heterocyclic bases.
Additional Material:
8 Ill.
Type of Medium:
Electronic Resource
