ISSN:
0006-3525
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
NMR spectra of cyclo(tri-L-prolyl), c-(P)3, show large shifts of the Hα resonance on adding C6D6 to a solution of c-(P)3 in CD2Cl2. CPK models and observed coupling constants indicate a rigid c-(P)3 conformation, independent of solvent composition, suggesting that these shifts result from formation of stereospecific C6D6-c-(P)3 collision complexes in which the c-(P)3 Hα lie near the face of the aromatic ring. The temperature dependence of the Hα shifts and the solvent dependent shifts observed on adding toluene-d8 or nitrobenzene-d5 to the c-(P)3 solution suggest that preferred C6D6-c-(P)3 orientations result from attractive interactions between the electron-rich aromatic ring and the electropositive Hα's and/or δ+ nitrogen atoms in the peptide backbone. Reports of such interactions in increasingly diverse peptide model systems suggest that they may play a role in stabilizing protein structures.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bip.1972.360110310
