ISSN:
0006-3525
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
5′-8NH2GMP forms an ordered structure in moderately acid (pD 4.7) solution. We propose for this ordered form a novel hemiprotonated G·G structure with a twofold rotation axis and three hydrogen bonds between each pair of guanine residues. Gel formation does not occur with this nucleotide in either neutral or acid solution. In neutral solution 5′-8NH2GMP also forms a regular, ordered structure, quite different from the acid form and similar to that formed by 5′-GMP under the same neutral conditions. We suggest that this ordered structure consists of a regularly stacked array of planar tetramers, similar to that proposed for 3′-GMP at pH 5.2
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bip.1975.360141009
