ISSN:
0006-3525
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Two series of peptides containing L-phenylalanine, Nps-(L-Phe-L-Phe-Gly)n-OEt (n = 1-6) and Nps-(L-Phe-L-Leu-Gly)n-OEt (n = 1-7), were prepared by the fragment-condensation method using the tripeptide N-hydroxysuccinimide esters. Conformational characterization of these peptides in the solid state was performed by ir spectroscopy and x-ray powder diffraction measurement. The peptides Nps-(L-Phe-L-Phe-Gly)n-OEt take the β-structure, but the pentadecapeptide and higher peptides of Nps-(L-Phe-L-Leu-Gly)n-OEt form the α-helix, although the lower homologs take the β-structure.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bip.1981.360201004