ISSN:
0006-3525
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A systematic survey has been made, using molecular mechanics, of the conformation of the ring entity of the enkephalin analogs, [D-Cys2-L-Cys5]-enkephalinamide and [D-Cys2-D-Cys5]enkephalinamide. These molecules are considerably more flexible than the analog Tyr-cyclo(Nγ-D-A2bu-Gly-Phe-Leu-), but the favored conformations of all three are very similar. The results of these studies are compatible with a Gly3-Phe4 type II′ bend in the active conformation of enkephalin.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bip.360231114