ISSN:
0006-3525
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Soluble fibronectin binds specifically and saturably to surfaces of substrate-attached cells. Bound fibronection is then transferred to the deoxycholate-insoluble extracellular matrix. During transfer, fibronectin is translocated from the cell surface and organized into disulfide-bonded multimers by disulfide exchange. Binding is mediated by disulfidelooped, type I homology “fingers” in the amino-terminal region. Exchange involves disulfides in the same amino-terminal region.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bip.360240116