ISSN:
0006-3525
Keywords:
solid-phase peptide synthesis
;
solid-phase combinatorial chemistry
;
chemical libraries
;
polyethylene glycol-polystyrene (PEG-PS)
;
polymeric supports
;
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The choice of a polymeric support is a key factor for the success of solid-phase methods for syntheses of organic compounds and biomolecules such as peptides and oligonucleotides. Classical Merrifield solid-phase peptide synthesis (SPPS), performed on low cross-linked hydrophobic polystyrene (PS) beads, sometimes suffers from sequence-dependent coupling difficulties. The concept of incorporating polyethylene glycol (PEG) into supports for solid-phase synthesis represents a successful approach to alleviating such problems. Previous reports from our laboratories have shown the advantages of “low-load” PEG-PS (0.15-0.25 mmol/g) for SPPS. Herein, we demonstrate that the beneficial aspects of the PEG-PS concept can be extended with resins that have higher loadings (0.3-0.5 mmol/g). © 1999 John Wiley & Sons, Inc. Biopoly 47: 365-380, 1998
Additional Material:
10 Ill.
Type of Medium:
Electronic Resource