ISSN:
0887-3585
Keywords:
protein structure prediction
;
β-strand
;
potential of mean force
;
Hidden Markov model
;
multiple sequence alignment
;
Chemistry
;
Biochemistry and Biotechnology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
Notes:
Protein structure predictions were submitted for 9 of the target sequences in the competition that ran during 1994. Targets sequences were selected that had no known homology with any sequence of known structure and were members of a reasonably sized family of related but divergent sequences. The objective was either to recognize a compatible fold for the target sequence in the database of known structures or to predict ab initio its rough 3D topology. The main tools used were Hidden Markov models (HMM) for fold recognition, a β- strand pair potential to predict β-sheet topology, and the PHD server for secondary structure prediction. Compatible folds were correctly identified in a number of cases and the β-strand pair potential was shown to be a useful tool for ab initio topology prediction. © 1995 Wiley-Liss, Inc.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/prot.340230313
