ISSN:
0570-0833
Keywords:
Carbacyclin
;
Prostaglandins
;
Prostacyclins
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The prostanoids continue to attract a great deal of attention, particularly in the pharmacological sector. Many of the numerous biological studies on prostaglandins deal with their cardiovascular effects. The pronounced antihypertensive and platelet aggregation-inhibiting properties of prostacyclin (PGI2) resulted in world-wide efforts to synthesize acid-stable analogues of the natural product. Whereas refined analytical procedures disproved the hypothesis that PGI2 is a circulating hormone, exploratory human trials with PGI2 confirmed the pharmacological findings obtained from animal experiments. Clinical studies of PGI2 analogues have been started. In vitro studies on isolated vessels revealed that potent cardiovascular drugs stimulate prostacyclin synthesis; however, it has not as yet been possible to demonstrate whether these effects are also of therapeutic significance. A survey of the PGI2 analogues synthesized so far is presented, and, with the aid of a few examples, the problems encountered during their synthesis are outlined; structure-activity relationships are also discussed.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/anie.198207511
