ISSN:
0003-276X
Keywords:
Life and Medical Sciences
;
Cell & Developmental Biology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
Notes:
Five-day-old female rats were made anovulatory by injection of 50 μg testosterone propionate. When the animals were at least 120 days old, corpora lutea (CL) were induced by injection of human chorionic gonadotrophin (HCG). Various treatments were initiated 15 days after HCG and the morphological regression of induced CL was examined 30 days after HCG. Structural luteolysis was very slight in control animals, suggesting that prolactin secretion was minimal. Exogenous prolactin hastened the rate of luteal regression. Daily injections of estradiol or reserpine also caused rapid structural luteolysis. Destruction of the arcuate nucleus of the hypothalamus also induced morphological regression at a more rapid rate than in controls. In conclusion, exogenous prolactin or three different treatments known to promote secretion of endogenous prolactin accelerated the rate of luteal regression in induced CL.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/ar.1091650106
