Electronic Resource
New York, NY [u.a.]
:
Wiley-Blackwell
The @Anatomical Record
197 (1980), S. 331-337
ISSN:
0003-276X
Keywords:
Life and Medical Sciences
;
Cell & Developmental Biology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
Notes:
Pressure-volume characteristics of whole lungs were measured in euthyroid rats and in rats fed 0.4% desiccated thyroid for eight weeks. The lungs were degassed by incising the diaphragm after the animals had breathed 100% oxygen for ten minutes. The pressure-volume characteristics were measured by inflating and deflating the lungs at a rate of 3.5 cc/min. Total lung capacity (TLC) was considered to be that volume of air required to produce a transpulmonary pressure of 30 cm H2O. At TLC there was 35% greater lung volume in the thyroid-treated animals than in their littermate controls. Similar results were observed in saline-filled lungs. Alveolar surface area (Sa) increased from 0.28m2 in the lungs of control animals to 0.75m2 in lungs of thyroid-treated animals. There was an 85% increase in the alveolar surface density (Sva) in the thyroid-treated animals. These results, obtained by morphometric analysis, suggest that greater lung volume in the thyroid-treated animals resulted from alveolar hyperplasia or „partitioning“.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/ar.1091970307
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