ISSN:
0021-9541
Keywords:
Life and Medical Sciences
;
Cell & Developmental Biology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
,
Medicine
Notes:
Type β transforming growth factors are a group of homologous structurally related polypeptides that act on a wide variety of cell types to alter their proliferative and phenotypic properties. TGF-βs form a group within a larger family of polypeptides that control developmental processes in organisms from humans to Drosophila. We have found that at least three distinct forms of TGF-β are present in mammalian tissues. We have identified a family of cell surface glycoproteins that bind TGF-βs with high affinity and specificity. Examination of the interactions between individual forms of TGF-β and the individual TGF-β receptor species has illustrated a complex pattern of ligand-receptor associations. Occupancy of a particular receptor type by TGF-β can be correlated to the dictation of specific effects on cell proliferation and cell differentiation.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jcp.1041330409
