ISSN:
0148-7280
Schlagwort(e):
fertilization
;
postacrosomal sheath
;
sperm
;
zona-free hamster egg penetration
;
Life and Medical Sciences
;
Cell & Developmental Biology
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Biologie
Notizen:
We selected 17 infertile men whose sperm ultrastructural study revealed at least 70% of spermatozoa with postacrosomal sheath (PAS) anomalies. Among the other sperm head defects, those affecting the nuclear shape were most frequently encountered and were highly correlated with PAS anomalies (r = +0.71; P 〈 .01). PAS anomalies were also correlated with chromatin condensation defects (r = +0.67; P 〈 .01) and acrosome anomalies (r = +0.53; P 〈.05). Those spermatozoa were tested for their ability to penetrate zona-free hamster oocytes and were compared to a control sperm population. It was shown that sperm head morphological anomalies impaired the ability of spermatozoa to attach to and penetrate the oocyte. The highest significant and negative correlations were found between the penetration rate and 1) the percentage of spermatozoa with PAS anomalies (r = -0.81; P 〈 .01) and 2) the percentage of spermatozoa with nuclear shape anomalies (r = -0.66; P 〈 .01). The effect of PAS anomalies on human fertilization process are discussed.
Zusätzliches Material:
8 Ill.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/mrd.1120170206
