ISSN:
0947-3440
Keywords:
Glycosphingolipids
;
Gangliosides
;
Starfish
;
Astropecten latespinosus
;
Antitumor activity
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Two ganglioside molecular species [LG-1 (1) and LG-2 (5)] have been obtained from the water-soluble lipid fraction of the chloroform/methanol extract of the starfish Astropecten latespinosus. On the basis of chemical and spectroscopic findings, the structure of 1 and 5 have been elucidated. They are new ganglioside molecular species. Negative FAB mass spectrometry provided important information both on the structure of the sugar moiety and on the molecular mass of the gangliosides. Partial hydrolysis by hot water has proved useful for structure elucidation of the complex oligosaccharide moieties. In addition, the major ganglioside molecular species, LG-2 (5), shows antitumor activity against murine lymphoma L1210 cells in vitro.
Additional Material:
2 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.199519950374