ISSN:
0947-6539
Keywords:
oligomers
;
polyethers
;
tetrahydrofurans
;
Williamson reaction
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Oligo(tetrahydrofurans) (oligo-THFs) 8-12 have been synthesised stereoselectively. Multiple Williamson reactions were used as key steps. While oligo-THFs with an even number of THF rings like the bi-THFs 8 and 9 as well as the tetra-THFs 10 and 11 were obtained by a bidirectional strategy, the penta-THF 12 with an odd number of THF rings was prepared by a convergent strategy with a sulfone-aldehyde coupling as connecting step. The oligo-THF products are important structural features of natural (Annonaceae acetogenins) and non-natural (artificial ion channels) products.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/chem.19970030723
