ISSN:
0947-6539
Keywords:
antitumor agents
;
DNA
;
NMR spectroscopy
;
platinum
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The propensity of the phospho-diester group to bind platinum(II) was investigated by examining the reactions of the dinucleotide salts NH4{d(TpT)} and NH4{d(TpG)} with the complexes [Pt-(NO3)(NH3)3]NO3 (1) and cis-[Pt(NO3)2-(NH3)2] (2) in N,N-dimethylformamide. d(TpT)- coordinates to the platinum atom of both 1 and 2 through either of the two nonbridging phosphoryl oxygen atoms, as revealed by 31P NMR spectroscopy. Conversely, d(TpG)- binds to 1 through the guanine N7 atom. With 2, d(TpG)- forms monodentate adducts bound to N7(G), as well as two distinct macrochelates, in which N7(G) and one of the nonbridging phosphoryl oxygens are crosslinked by platinum. We suggest that guanine-phosphoryl macrochelate complexes play a role as intermediates in rearrangements of platinum monoadducts formed with DNA.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/chem.19970030906
