ISSN:
0009-2940
Keywords:
Chemistry
;
Inorganic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Description / Table of Contents:
N.N-Disubstituted 2-Aminocyclobutanones from 2-Hydroxycyclobutanones and Secondary AminesN.N-Disubstituted 2-aminocyclobutanones (7) are readily formed under mild conditions by reaction of 2-aminocyclobutanones (7) are readily formed under mild conditions by reaction of 2-hydroxycyclobutanone (6) with secondary amines in solution at room temperature. Optimum yields are obtained when 6 - prepared by hydrolysis of 1.2-bis(trimethylsiloxy)cyclobut-1-ene (8) - reacts in situ. By this method derivatives of 7 as well as higher homologous 2-aminocycloalkanones are also easily prepared.
Notes:
2-Hydroxy-cyclobutanon (6) reagiert bei 20° in Lösung glatt mit sekundären Aminen zu den N.N-disubstituierten 2-Amino-cyclobutanonen (7). Optimale Ausbeuten an 7 lassen sich erzielen, wenn 6 in situ - dargestellt durch Hydrolyse des 1.2-Bis-trimethylsiloxy-cyclo-butens-(1) (8) - umgesetzt wird. Auf diese Weise sind auch Derivate von 7 sowie höherhomologe 2-Amino-cycloalkanone leicht erhältlich.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/cber.19721050328
