ISSN:
0009-2940
Keywords:
Chemistry
;
Inorganic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Description / Table of Contents:
Building Units for Oligosaccharides, V. Synthesis of Dihydrostreptosyl-deoxystreptamineReaction of the streptosyl chloride 1 and the streptosyl bromide 6 with the racemie mixture of the 2-deoxystreptamine derivative 2 leads to diastereoisomeric mixtures of the α-glycosidic bonded pscudo-disaccharides, which can be separated by column chromatography. Complete deblocking, affording the pseudo-disaccharides of 4-O- and 6-O-linked dihydrostreptosyl-2-deoxystreptamines 10 a and 10 b, is possible in the case of compounds 8 a and 8 b, which are protected by the benzylidene group in the streptose moiety.
Notes:
Das Streptosylchlorid 1 und das Streptosylbromid 6 reagieren mit dem racemischen 2-Desoxy-streptamin-Derivat 2 zu trennbaren Diastereomerengemischen der α-glycosidisch verknüpften Pseudodisaccharide. Im Falle der mit der Benzylidengruppe im Streptose-Teil geschützten Produkte 8 a und 8 b ist eine vollständige Entblockierung zu den Pseudodisacchariden des 4-O- und 6-O-verknüpften Dihydrostreptosyl-2-desoxystreptamins 10 a und 10 b gelungen.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/cber.19771100535
