ISSN:
0009-2940
Keywords:
Chemistry
;
Inorganic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Reactions of Oxazolin-5-one Anions, IX. A Simple Procedure for the Preparation of δ-Aminolevulinic Acid Derivatives and Related CompoundsCyclization of Z-dipeptides 1 with acetic anhydride leads to 2-oxazolin-5-ones, which yield the corresponding 3-oxazolin-5-ones 2 by base-catalyzed addition of ethyl acrylate or acrylonitrile. Hydrolysis of 2a gives ethyl δ-(benzyloxycarbonylamino)levulinate (3a), which may be converted into several N-protected derivatives 3e - i. Via the same procedure the homologue 3b and the nitriles 3c, d are easily obtained.
Additional Material:
3 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/cber.19801130235