ISSN:
0009-2940
Keywords:
Marine natural products
;
Hemiketal formation, selective
;
Denticulatins
;
Chemistry
;
Inorganic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The total synthesis of the denticulatins 1 is described. Key feature is the efficient generation of the C-1-to-C-9 building block 37 by three consecutive stereoselective carbon - carbon bond-forming steps using chiral allylboronates. The C-10-to-C-17 building block was obtained by kinetic Sharpless resolution of an allylic alcohol followed by an Ireland-Claisen rearrangement.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/cber.19911240940