ISSN:
0009-2940
Keywords:
Vanadium alkoxides
;
Haptens
;
NMR, 51V
;
Chemistry
;
Inorganic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Several new oxovanadium alkoxides and alkoxides/chlorides of the composition VOCl3-n(OR)n (n = 1, R = CPh3; n = 2 and 3, R = CPh3, iBu, cyclopentyl, tert-pentyl, octyl; n = 3, R = dodecyl, 3-methylbutyl) and the mixed ester VO(OiBu)- (OCPh3)2 have been prepared. The compounds VO(OiBu)2OR' have been synthesized, where R' is a functionalized long-chain alkyl group [ - (CH2)8OH, - (CH2)6NH(FMOC), - (CH2)6NH2, - C(O)(CH2)5C(O)OMe, p-C6H4CN, p-C6H4NH2]. The chloride/carboxylate VOCl2{O2C(CH2)5CO2H} has also been obtained. The compounds are characterized, inter alia, by 51V-NMR spectroscopy. Typical 51V shift ranges are observed for specific ligand functionalities (chloride, alkoxide, carboxylate). δ(51V) values also depend on the steric requirement of the groups R and the coordination number. The importance of the functionalized esters as potential triggers for the production of abzymes with phosphatase activity is discussed.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/cber.19911241017
