ISSN:
1434-193X
Keywords:
Addition reactions
;
Diastereoselectivity
;
2′-Hydroxychalcones
;
3-Aryl-1,5-bis(2-hydroxyphenyl)-2,4-dimethyl-1,5-pentanediones
;
NMR spectroscopy
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The diastereoselective synthesis of 3-aryl-1,5-bis(2-hydroxyphenyl)-2,4-dimethyl-1,5-pentanediones has been carried out by conjugate addition reactions of 2′-hydroxypropiophenone to 2′-hydroxy-α-methylchalcone derivatives, or in single one-pot reactions of 2′-hydroxypropiophenone with appropriate benzaldehyde derivatives. The structures and stereochemistry of the obtained diastereomers have been determined using various NMR techniques, and the factors determining their formation are investigated and discussed.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource