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A Short and Efficient Synthesis of (2S,2′R,3′R)-2-(2′,3′-Dicarboxylcyclopropyl)glycine (DCG-IV) (1999)

Wichmann, Jürgen ; Adam, Geo

Weinheim : Wiley-Blackwell

Liebigs Annalen 1999 (1999), S. 3131-3133

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ISSN: 1434-193X

Keywords: Amino acids ; DCG-IV ; Drug research ; m-Glu receptors ; Stereocontrol ; Chemistry ; General Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: Feist′s acid (5) was used in enantiomerically pure form as starting material for the synthesis of (2S,2′R,3′R)-2-(2′,3′-dicarboxylcyclopropyl)-glycine (DCG-IV) (2). This conformationally restricted analog of L-glutamic acid (L-Glu) 1 is a potent group II mGlu receptor agonist.

Additional Material: 1 Ill.

Type of Medium: Electronic Resource

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