ISSN:
0268-2605
Keywords:
thiosemicarbazones
;
metal complexes
;
anti-inflammatory
;
Chemistry
;
Industrial Chemistry and Chemical Engineering
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The thiosemicarbazones and their related metal complexes were shown to be potent anti-inflammatory agents in rodents at 8 mg kg-1. They were effective in blocking induced edema and endotoxic shock while blocking both local and central pain processes. The ability of the agents to function as anti-inflammatory agents is multifold. First, Tumor Necrosis Factor-alpha (TNFα) and Interleukin-1 (IL-1) release was markedly reduced by the agents. Second, high-affinity receptor binding on fibroblasts of TNFα and IL-1 was significantly inhibited. Third, cellular events, e.g. lysosomal enzymes of specific cells, such as macrophages, were inhibited and prostaglandin cyclo-oxygenase and leukotriene 5′-lipoxygenase enzymic synthetic rates were significantly reduced, which should cause an overall reduction of the inflammatory process.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
