ISSN:
0268-2605
Keywords:
bile acids
;
conjugated bile acids
;
trimethylsilyl (TMS) derivatives
;
GLC-MS analysis
;
Chemistry
;
Industrial Chemistry and Chemical Engineering
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The trimethylsilyl (TMS) derivatives of a mixture of nine bile acids (six free and three conjugated), namely lithocholic, deoxycholic, chenocholic, cholic, hyodeoxycholic, ursodeoxycholic, glycodeoxycholic, glycocholic and glycochenodeoxycholic acids, have been prepared by a new, simple, efficient derivatization procedure, based on the use of a mixture of N-methyl-N-trimethylsilyl-1,1,1- trifluoroacetamide and 1-(trimethylsilyl)imidazole, as the silylating agent. The above-mentioned bile acids were completely trimethylsilylated on all hydroxyl and carboxyl groups whereas carbonyl and amino groups remained untouched.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
